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Burns are a global health problem and can be caused by several factors, including ultraviolet (UV) radiation. Exposure to UVB radiation can cause sunburn and a consequent inflammatory response characterised by pain, oedema, inflammatory cell infiltration, and erythema. Pharmacological treatments available to treat burns and the pain caused by them include nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, antimicrobials and glucocorticoids, which are associated with adverse effects. Therefore, the search for new therapeutic alternatives is needed. Diosmetin, an aglycone of the flavonoid diosmin, has antinociceptive, antioxidant and anti-inflammatory properties. Thus, we evaluated the antinociceptive and anti-inflammatory effects of topical diosmetin (0.01, 0.1 and 1%) in a UVB radiation-induced sunburn model in mice. The right hind paw of the anaesthetised mice was exposed only once to UVB radiation (0.75 J/cm 2 ) and immediately treated with diosmetin once a day for 5 days. The diosmetin antinociceptive effect was evaluated by mechanical allodynia and pain affective-motivational behaviour, while its anti-inflammatory activity was assessed by measuring paw oedema and polymorphonuclear cell infiltration. Mice exposed to UVB radiation presented mechanical allodynia, increased pain affective-motivational behaviour, paw oedema and polymorphonuclear cell infiltration into the paw tissue. Topical Pemulen® TR2 1% diosmetin reduced the mechanical allodynia, the pain affective-motivational behaviour, the paw oedema and the number of polymorphonuclear cells in the mice's paw tissue similar to that presented by Pemulen® TR2 0.1% dexamethasone. These findings indicate that diosmetin has therapeutic potential and may be a promising strategy for treating patients experiencing inflammatory pain, especially those associated with sunburn.

Titel:	Topical diosmetin attenuates nociception and inflammation in a ultraviolet B radiation-induced sunburn model in mice.
Autor/in / Beteiligte Person:	Favarin, A ; Becker, G ; Brum, ES ; Serafini, PT ; Marquezin, LP ; Brusco, I ; Oliveira, SM
Link:	Full Text Finder (Volltext)
Zeitschrift:	Inflammopharmacology, 2024-06-22
Veröffentlichung:	Ahead of Print, 2024
Medientyp:	academicJournal
ISSN:	1568-5608 (electronic)
DOI:	10.1007/s10787-024-01507-x
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Inflammopharmacology] 2024 Jun 22. <i>Date of Electronic Publication: </i>2024 Jun 22. References: Adamante G, Spring De Almeida A, Rigo FK et al (2019) Diosmetin as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive activity in mice. Life Sci 216:215–226. https://doi.org/10.1016/j.lfs.2018.11.029. (PMID: 10.1016/j.lfs.2018.11.02930447303) ; Basbaum AI, Bautista DM, Scherrer G, Julius D (2009) Cellular and molecular mechanisms of pain. Cell 139:267–284. https://doi.org/10.1016/j.cell.2009.09.028. (PMID: 10.1016/j.cell.2009.09.028198370312852643) ; Battie C, Jitsukawa S, Bernerd F et al (2014) New insights in photoaging, UVA induced damage and skin types. Exp Dermatol 23:7–12. https://doi.org/10.1111/exd.12388. 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(PMID: 10.1016/0304-3959(83)90201-46877845) Grant Information: #21/2551-0001966-2 Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; #309404/2023-1 Conselho Nacional de Desenvolvimento Científico e Tecnológico; #150611/2022-6 Conselho Nacional de Desenvolvimento Científico e Tecnológico; process #88881.844988/2023-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Grant #1333/2023 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; #88887.568915/2020-00 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Contributed Indexing: Keywords: Anti-inflammatory; Antinociception; Burn; Natural compound; Pain Entry Date(s): Date Created: 20240622 Latest Revision: 20240622 Update Code: 20240623

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Topical diosmetin attenuates nociception and inflammation in a ultraviolet B radiation-induced sunburn model in mice.