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Titel:	The possible mechanisms of action of progestins on endometrial adenocarcinoma.
Autor/in / Beteiligte Person:	Anderson, DG
Zeitschrift:	American journal of obstetrics and gynecology, Jg. 113 (1972-05-15), Heft 2, S. 195-211
Veröffentlichung:	<2005->: New York : Elsevier ; <i>Original Publication</i>: St. Louis., 1972
Medientyp:	academicJournal
ISSN:	0002-9378 (print)
DOI:	10.1016/0002-9378(72)90769-7
Schlagwort:	17-Hydroxycorticosteroids urine 17-Ketosteroids urine Adenocarcinoma pathology Aged Biopsy Blood Cell Count Blood Protein Electrophoresis Endometrium pathology Estrogens urine Female Follicle Stimulating Hormone antagonists & inhibitors Gonadotropins, Pituitary antagonists & inhibitors Humans Immunity drug effects Luteinizing Hormone antagonists & inhibitors Lymphocytes Medroxyprogesterone pharmacology Middle Aged Palliative Care Pregnanediol urine Remission, Spontaneous Time Factors Adenocarcinoma drug therapy Medroxyprogesterone therapeutic use Uterine Neoplasms drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Am J Obstet Gynecol] 1972 May 15; Vol. 113 (2), pp. 195-211. MeSH Terms: Adenocarcinoma / drug therapy ; Medroxyprogesterone / therapeutic use ; Uterine Neoplasms / drug therapy ; 17-Hydroxycorticosteroids / urine ; 17-Ketosteroids / urine ; Adenocarcinoma / pathology ; Aged ; Biopsy ; Blood Cell Count ; Blood Protein Electrophoresis ; Endometrium / pathology ; Estrogens / urine ; Female ; Follicle Stimulating Hormone / antagonists & inhibitors ; Gonadotropins, Pituitary / antagonists & inhibitors ; Humans ; Immunity / drug effects ; Luteinizing Hormone / antagonists & inhibitors ; Lymphocytes ; Medroxyprogesterone / pharmacology ; Middle Aged ; Palliative Care ; Pregnanediol / urine ; Remission, Spontaneous ; Time Factors Contributed Indexing: Indexing Agency: PIP Local ID #: 720743. Indexing Agency: POP Local ID #: 00003321. ; Keywords: Biology; Cancer; Clinical Research; Contraception; Contraceptive Agents, Female--therapeutic use; Contraceptive Agents, Progestin--therapeutic use; Contraceptive Agents--therapeutic use; Contraceptive Effectiveness; Cytologic Effects; Depo-provera--therapeutic use; Diseases; Endometrial Cancer; Evaluation; Family Planning; Immunity; Immunological Effects; Injectables; Medroxyprogesterone Acetate--therapeutic use; Neoplasms; Physiology; Research Methodology; Steroid Metabolic Effects; Use-effectiveness ; Local Abstract: [PIP] To investigate the effect of medroxyprogesterone acetate therapy upon the immune response and endogenous status of patients with primary or recurrent endometrial adenocarcinoma, 8 patients were treated with progestin therapy as inpatients for 33-80 days. Patients were studied intermittently for up to 72 months. Serum protein electrophoresis during treatment showed no change in protein pattern. In all 8 patients, there was a suppression of pituitary gonadotrophin. There was no evidence that the adenocarcinomas were suppressed by either an immunologic mechanism or by the variation in endogenous hormone production. Investigation should be continued to study the effects of medroxyprogesterone acetate on the cellular level. Substance Nomenclature: 0 (17-Hydroxycorticosteroids) ; 0 (17-Ketosteroids) ; 0 (Estrogens) ; 0 (Gonadotropins, Pituitary) ; 9002-67-9 (Luteinizing Hormone) ; 9002-68-0 (Follicle Stimulating Hormone) ; HSU1C9YRES (Medroxyprogesterone) ; JR3JD1Y22C (Pregnanediol) Entry Date(s): Date Created: 19720515 Date Completed: 19720721 Latest Revision: 20190615 Update Code: 20231215

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The possible mechanisms of action of progestins on endometrial adenocarcinoma.