Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13.

Hua, X ; Wu, J ; et al.

In: Genomics, Jg. 25 (1995-02-10), Heft 3, S. 667-73

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Sterol regulatory element binding protein-1 (SREBP1) and SREBP2 are structurally related proteins that control cholesterol homeostasis by stimulating transcription of sterol-regulated genes, including those encoding the low-density lipoprotein (LDL) receptor and 3-hydroxy-3-methylglutaryl CoA synthase. SREBP1 and SREBP2 are 47% identical, and they share a novel structure comprising a transcriptionally active NH2-terminal basic helix-loop-helix-leucine zipper (bHLH-Zip) domain followed by a membrane attachment domain. Cleavage by a sterol-regulated protease frees the bHLH-Zip domain from the membrane and allows it to enter the nucleus. SREBP1 exists in several forms, possibly as a result of alternative splicing at both the 5' and the 3' ends of the mRNA. The genes for SREBP1 (SREBF1) and SREBP2 (SREBF2) have not been studied. In this paper we describe the cloning and characterization of the human SREBF1 gene. The gene is 26 kb in length and has 22 exons and 20 introns. The 5' and 3' sequences that differ between the two SREBP1 cDNAs are encoded by discrete exons, confirming the hypothesis that they result from alternative splicing. The chromosomal locations of human SREBF1 and SREBF2 were determined by analysis of human-rodent somatic cell hybrids and fluorescence in situ hybridization. The SREBF1 gene mapped to the proximal short arm of chromosome 17 (17p11.2), and the SREBF2 gene was localized to the long arm of chromosome 22 (22q13).

Titel:	Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13.
Autor/in / Beteiligte Person:	Hua, X ; Wu, J ; Goldstein, JL ; Brown, MS ; Hobbs, HH
Link:	Full Text Finder (Volltext)
Zeitschrift:	Genomics, Jg. 25 (1995-02-10), Heft 3, S. 667-73
Veröffentlichung:	San Diego : Academic Press, [c1987-, 1995
Medientyp:	academicJournal
ISSN:	0888-7543 (print)
DOI:	10.1016/0888-7543(95)80009-b
Schlagwort:	Alternative Splicing Animals Base Sequence Chromosome Mapping Cloning, Molecular Cricetinae DNA Exons Humans Hybrid Cells Introns Mice Molecular Sequence Data Sterol Regulatory Element Binding Protein 1 Sterol Regulatory Element Binding Protein 2 CCAAT-Enhancer-Binding Proteins Chromosomes, Human, Pair 17 Chromosomes, Human, Pair 22 DNA-Binding Proteins genetics Nuclear Proteins genetics Transcription Factors genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Language: English [Genomics] 1995 Feb 10; Vol. 25 (3), pp. 667-73. MeSH Terms: CCAAT-Enhancer-Binding Proteins* ; Chromosomes, Human, Pair 17* ; Chromosomes, Human, Pair 22* ; DNA-Binding Proteins / genetics ; Nuclear Proteins / genetics ; Transcription Factors / *genetics ; Alternative Splicing ; Animals ; Base Sequence ; Chromosome Mapping ; Cloning, Molecular ; Cricetinae ; DNA ; Exons ; Humans ; Hybrid Cells ; Introns ; Mice ; Molecular Sequence Data ; Sterol Regulatory Element Binding Protein 1 ; Sterol Regulatory Element Binding Protein 2 Grant Information: HL20948 United States HL NHLBI NIH HHS Gene Symbol: SREBF1; SREBF2 Substance Nomenclature: 0 (CCAAT-Enhancer-Binding Proteins) ; 0 (DNA-Binding Proteins) ; 0 (Nuclear Proteins) ; 0 (SREBF1 protein, human) ; 0 (SREBF2 protein, human) ; 0 (Srebf1 protein, mouse) ; 0 (Srebf2 protein, mouse) ; 0 (Sterol Regulatory Element Binding Protein 1) ; 0 (Sterol Regulatory Element Binding Protein 2) ; 0 (Transcription Factors) ; 9007-49-2 (DNA) Entry Date(s): Date Created: 19950210 Date Completed: 19950629 Latest Revision: 20220310 Update Code: 20231215

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