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Mice injected with carrageenin in the footpad developed local inflammation which peaked at 48 hr. This was significantly reduced in mice inoculated orally with an attenuated Salmonella construct expressing transforming growth factor-beta (TGF-beta). Administration of the Salmonella construct alone had no effect on inflammation. High levels of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) were secreted by draining lymph node cells from mice injected with carrageenin following stimulation in vitro. Prior inoculation with Salmonella enhanced the production of IL-2 and IFN-gamma from the draining lymph node cells. Administration of the Salmonella-TGF-beta construct significantly inhibited the production of these cytokines. In contrast, IL-10 only was secreted from draining lymph node cells of animals inoculated with the Salmonella-TGF-beta construct. Thus, oral administration of TGF-beta can significantly inhibit local inflammation and alter the cytokine secretion pattern of cells from lymph nodes draining the site of inflammation.

Titel:	Expression of TGF-beta in attenuated Salmonella typhimurium: oral administration leads to the reduction of inflammation, IL-2 and IFN-gamma, but enhancement of IL-10, in carrageenin-induced oedema in mice.
Autor/in / Beteiligte Person:	Ianaro, A ; Xu, D ; O'Donnell, CA ; Di Rosa, M ; Liew, FY
Link:	Full Text Finder (Volltext)
Zeitschrift:	Immunology, Jg. 84 (1995), Heft 1, S. 8-15
Veröffentlichung:	Oxford : Blackwell Scientific Publications, 1995
Medientyp:	academicJournal
ISSN:	0019-2805 (print)
Schlagwort:	Administration, Oral Animals Carrageenan administration & dosage DNA Primers Disease Models, Animal Female Inflammation immunology Lymph Nodes metabolism Mice Mice, Inbred BALB C Molecular Sequence Data Plasmids Polymerase Chain Reaction Transforming Growth Factor beta genetics Transforming Growth Factor beta therapeutic use Inflammation therapy Interferon-gamma metabolism Interleukin-10 metabolism Interleukin-2 metabolism Salmonella typhimurium Transduction, Genetic Transforming Growth Factor beta administration & dosage
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Immunology] 1995 Jan; Vol. 84 (1), pp. 8-15. MeSH Terms: Salmonella typhimurium* ; Transduction, Genetic* ; Inflammation / therapy ; Interferon-gamma / metabolism ; Interleukin-10 / metabolism ; Interleukin-2 / metabolism ; Transforming Growth Factor beta / *administration & dosage ; Administration, Oral ; Animals ; Carrageenan / administration & dosage ; DNA Primers ; Disease Models, Animal ; Female ; Inflammation / immunology ; Lymph Nodes / metabolism ; Mice ; Mice, Inbred BALB C ; Molecular Sequence Data ; Plasmids ; Polymerase Chain Reaction ; Transforming Growth Factor beta / genetics ; Transforming Growth Factor beta / therapeutic use References: Infect Immun. 1992 Oct;60(10):3994-4002. (PMID: 1398911) ; J Immunol. 1988 Jun 15;140(12):4217-23. (PMID: 3131428) ; J Exp Med. 1993 Jan 1;177(1):225-30. (PMID: 8418203) ; J Exp Med. 1993 Feb 1;177(2):523-7. (PMID: 8426121) ; Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3442-6. (PMID: 7682701) ; Immunology. 1994 Jul;82(3):370-5. (PMID: 7959870) ; J Mol Biol. 1983 Jun 5;166(4):557-80. (PMID: 6345791) ; J Cell Biol. 1986 Apr;102(4):1217-23. (PMID: 3457014) ; J Immunol. 1986 May 15;136(10):3916-20. (PMID: 2871107) ; J Exp Med. 1986 May 1;163(5):1037-50. (PMID: 2871125) ; J Biol Chem. 1986 Oct 15;261(29):13426-9. (PMID: 2875996) ; J Immunol. 1986 Dec 15;137(12):3855-60. (PMID: 2878044) ; J Bacteriol. 1974 Sep;119(3):1072-4. (PMID: 4605400) ; J Immunol. 1988 Jun 15;140(12):4245-52. (PMID: 2967332) ; J Exp Med. 1988 Jul 1;168(1):25-32. (PMID: 3294331) ; Nature. 1988 Jul 21;334(6179):260-2. (PMID: 3041283) ; J Exp Med. 1988 Aug 1;168(2):543-58. (PMID: 2970518) ; J Immunol. 1989 Nov 1;143(9):2887-93. (PMID: 2530282) ; J Exp Med. 1989 Dec 1;170(6):2081-95. (PMID: 2531194) ; J Exp Med. 1990 Jan 1;171(1):231-47. (PMID: 2295877) ; J Immunol. 1990 May 1;144(9):3444-8. (PMID: 2139455) ; J Immunol. 1990 Aug 1;145(3):940-4. (PMID: 2115549) ; Trends Biotechnol. 1990 May;8(5):117-21. (PMID: 1366519) ; J Immunol. 1990 Oct 1;145(7):2281-5. (PMID: 2144549) ; J Clin Invest. 1991 Mar;87(3):1108-13. (PMID: 1999490) ; J Immunol. 1991 Mar 15;146(6):1849-57. (PMID: 1900875) ; Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2918-21. (PMID: 2011600) ; J Immunol. 1991 May 1;146(9):3012-7. (PMID: 1707929) ; J Exp Med. 1991 May 1;173(5):1121-32. (PMID: 2022923) ; J Immunol. 1991 May 15;146(10):3444-51. (PMID: 1827484) ; J Exp Med. 1991 Sep 1;174(3):539-45. (PMID: 1908509) ; J Immunol. 1991 Nov 1;147(9):2991-3000. (PMID: 1680924) ; J Exp Med. 1991 Nov 1;174(5):1209-20. (PMID: 1940799) ; Immunol Res. 1991;10(3-4):249-54. (PMID: 1955749) ; J Immunol. 1992 Feb 15;148(4):1176-81. (PMID: 1737934) ; Scand J Immunol. 1992 May;35(5):603-10. (PMID: 1349769) ; J Immunol. 1992 Jul 15;149(2):521-8. (PMID: 1624798) ; Science. 1992 Jul 24;257(5069):545-8. (PMID: 1636092) ; Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7375-9. (PMID: 1502148) ; Cell. 1987 Feb 13;48(3):409-15. (PMID: 2879635) ; J Immunol. 1987 Jun 1;138(11):3688-94. (PMID: 2953788) ; Proc Natl Acad Sci U S A. 1987 Aug;84(16):5788-92. (PMID: 2886992) ; Proc Natl Acad Sci U S A. 1987 Sep;84(17):6020-4. (PMID: 2888109) ; Science. 1988 Apr 15;240(4850):336-8. (PMID: 3281260) ; Cancer Immunol Immunother. 1988;26(2):95-100. (PMID: 2452015) ; J Immunol. 1988 May 1;140(9):3026-32. (PMID: 3129508) ; Eur J Immunol. 1992 Nov;22(11):2771-6. (PMID: 1425904) Grant Information: United Kingdom Wellcome Trust Substance Nomenclature: 0 (DNA Primers) ; 0 (Interleukin-2) ; 0 (Transforming Growth Factor beta) ; 130068-27-8 (Interleukin-10) ; 82115-62-6 (Interferon-gamma) ; 9000-07-1 (Carrageenan) Entry Date(s): Date Created: 19950101 Date Completed: 19950418 Latest Revision: 20181130 Update Code: 20231215 PubMed Central ID: PMC1415173

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Expression of TGF-beta in attenuated Salmonella typhimurium: oral administration leads to the reduction of inflammation, IL-2 and IFN-gamma, but enhancement of IL-10, in carrageenin-induced oedema in mice.