[Effect of ovariectomy and natural menopause on levels of selected pituitary hormones, 17-beta estradiol and lipid profile in blood serum].

Unlabelled: The main goal of this study was to measure changes in pituitary and sex hormone levels as a result of surgical or natural menopause, assess influences and correlation's between concentration of hormones and selected parameters of lipid profile important in the atherogenesis in the early period after surgical ovariectomy and during natural menopause. The first group consisted of 59 women (age +/- 3, 7) on whom hysterectomy with bilateral ovariectomy were performed. Blood samples were taken before operation and on 9th day after the operation. The second group consisted of 28 postmenopausal women (age 53 +/- 4). Methods hormonal measures were performed by radioimmunometric assays in blood serum (FSH, LH, PRL, 17-beta estradiol, testosterone, androstenedione and SHGB). The assessment of particular parameters of lipid profile: total cholesterol, HDL-C, LDL-C and triglycerides was performed by biochemical methods.

Results: We found statistically important, negative correlation between levels of estradiol and gonadotrophins; after surgical ovariectomy and natural menopause there are time depended changes in lipid profile. Early period after surgical ovariectomy is characterized by decrease in concentration of 17-beta estradiol and increase of atherogenic lipid parameters. Among postmenopausal women there is negative correlation between 17-beta estradiol concentration and atherogenic factor and total cholesterol. Changes of the lipid profile in the serum of the blood may be connected with hormonal homeostatic disturbances, decreased level of oestrogen's and rising level of gonadotrophins.