Pharmacokinetics of a 7-day 17 beta-estradiol transdermal delivery system: effect of application site and repeated applications on serum concentrations of estradiol and estrone.
In: Journal of clinical pharmacology, Jg. 36 (1996-11-01), Heft 11, S. 998-1005
academicJournal
Zugriff:
FemPatch (Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI), a new 7-day 17 beta-estradiol transdermal delivery system (TDS), has been developed for treatment of menopausal vasomotor symptoms. This two-period crossover study was conducted to determine the effects of TDS application site (buttocks versus abdomen) and early TDS replacement on estradiol and estrone concentrations, and to quantify intersubject and intrasubject pharmacokinetic variability. Eighteen healthy, postmenopausal female volunteers received a single 7-day TDS application to the abdomen and repeated TDS applications to the buttocks (regular replacement on days 7 and 14, intentional early replacement on day 17, and removal on day 21). Serial serum samples were assayed for estradiol and estrone by validated radioimmunoassay methods. The 7-day TDS delivers estradiol at a constant, near zero-order rate for the duration of application, independent of application site. Mean serum estradiol concentrations were higher after application to the buttocks than after application to the abdomen (19 and 15 pg/mL above baseline, respectively), making the buttocks the preferred site for TDS application. Mean serum concentration of estradiol was slightly higher (23 pg/mL above baseline) for the treatment week with early TDS replacement due to the transient increase in concentration over the first 24 hours after replacement. Parallel but smaller increases in concentrations of estrone were observed. Serum estradiol and estrone concentrations are reproducible within an individual from application to application (coefficient of variation, 25%). Variability between individuals was higher (coefficient of variation, 40-50%).
Titel: |
Pharmacokinetics of a 7-day 17 beta-estradiol transdermal delivery system: effect of application site and repeated applications on serum concentrations of estradiol and estrone.
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Autor/in / Beteiligte Person: | Boyd, RA ; Yang, BB ; Abel, RB ; Eldon, MA ; Sedman, AJ ; Forgue, ST |
Zeitschrift: | Journal of clinical pharmacology, Jg. 36 (1996-11-01), Heft 11, S. 998-1005 |
Veröffentlichung: | 2013- : Oxford : Wiley ; <i>Original Publication</i>: Stamford, Conn., Hall Associates., 1996 |
Medientyp: | academicJournal |
ISSN: | 0091-2700 (print) |
DOI: | 10.1177/009127009603601103 |
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