Association of Leishmania heat shock protein 83 antigen and immunoglobulin G4 antibody titers in Brazilian patients with diffuse cutaneous leishmaniasis.
In: Infection and immunity, Jg. 65 (1997-12-01), Heft 12, S. 5368-70
Online
academicJournal
Zugriff:
Diffuse cutaneous leishmaniasis (DCL) is characterized by the presence of numerous nonulcerated nodules and plaques containing large numbers of Leishmania amazonensis parasites and few lymphoid elements. The immune responses of DCL patients reflect severe antigen-specific T-cell deficiencies, while the antibody response to Leishmania antigens is often accentuated. We report herein on the Leishmania antigen-specific antibody subclass distribution in DCL patients and demonstrate that a dominant antigen contributing to the biased immunoglobulin G4 antibody subclass in sera of DCL patients is Leishmania heat shock protein 83.
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Association of Leishmania heat shock protein 83 antigen and immunoglobulin G4 antibody titers in Brazilian patients with diffuse cutaneous leishmaniasis.
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Autor/in / Beteiligte Person: | Skeiky, YA ; Benson, DR ; Costa, JL ; Badaro, R ; Reed, SG |
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Zeitschrift: | Infection and immunity, Jg. 65 (1997-12-01), Heft 12, S. 5368-70 |
Veröffentlichung: | Washington, DC : American Society For Microbiology ; <i>Original Publication</i>: [Bethesda, Md.] American Society for Microbiology., 1997 |
Medientyp: | academicJournal |
ISSN: | 0019-9567 (print) |
DOI: | 10.1128/iai.65.12.5368-5370.1997 |
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