Evidence for Non-Coding RNAs as Inherited Factors Influencing Cardiovascular Disease, Renal Disease and Tumorigenesis
2017
Hochschulschrift
Zugriff:
This dissertation is comprised of three projects. Projects 1 and 2 are focused on a GWAS locus for cardiovascular disease (short QT-interval) on human chromosome 17. We have previously validated and high resolution mapped the homologous genomic segment of this human locus to 1.5 (p < 0.05) in S versus R and SHR versus WKY, respectively. Using these circRNAs, circRNA/microRNA interaction was predicted as a feature occurring in rats. This is in-line with the knowledge that circRNAs serve as microRNA sponges to sequester microRNAs. Several circRNAs were further validated using quantitative real-time PCR. To our knowledge, our study is the first to profile circRNAs in renal tissue and illustrates that circRNAs could be candidate genetic factors controlling blood pressure.
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Evidence for Non-Coding RNAs as Inherited Factors Influencing Cardiovascular Disease, Renal Disease and Tumorigenesis
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Autor/in / Beteiligte Person: | Cheng, Xi |
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Veröffentlichung: | 2017 |
Medientyp: | Hochschulschrift |
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