Comparison of steroidogenic pathways among normoandrogenic and hyperandrogenic polycystic ovary syndrome patients and normal cycling women.
In: Journal of Obstetrics & Gynaecology Research, Jg. 41 (2015-02-01), Heft 2, S. 254-263
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Zugriff:
Aim To compare the corticosteroidogenic enzyme activities between normal cycling non-polycystic ovary syndrome ( PCOS), and normoandrogenic PCOS ( NA- PCOS) and hyperandrogenic PCOS ( HA-PCOS) patients. Methods This cohort study was conducted at Julio Muller University Hospital and Tropical Institute of Reproductive Medicine and Menopause, and enrolled 114 non- PCOS women and 355 PCOS patients. The steroidogenic enzyme activities were measured using the serum steroid product/precursor molar ratio. Results In the Δ5 pathway the 17,20 lyase activity was equally low in the NA-PCOS and HA-PCOS women compared with the non- PCOS women ( P < 0.01 and P < 0.001, respectively). In the Δ4 pathway, the 17,20 lyase activity was higher only in the HA-PCOS group ( P < 0.001). The 17-hydroxylase activity was the same in PCOS and non- PCOS subjects ( P > 0.05). The 3β-hydroxysteroid dehydrogenase II (3β- HSDII) activity was higher in the conversion of dehydroepiandrosterone into androstenedione in the HA-PCOS than in the NA-PCOS ( P < 0.05) and the non- PCOS patients ( P < 0.01). The aromatase activity was lower in the HA-PCOS than in the NA-PCOS ( P < 0.05) patients and non- PCOS subjects ( P < 0.01). In HA-PCOS subjects, the 17,20 lyase activity was related to insulin, estradiol, total testosterone concentrations and free androgen index in the Δ5 pathway. 3β- HSDII showed weak correlation with estradiol in the HA-PCOS group. Anthropometric parameters had little impact, if any, on the steroidogenic enzyme activities. Conclusion The NA-PCOS and HA-PCOS patients demonstrated different enzyme activities, and the results provided new directions for future studies including PCOS patients with different phenotypes. [ABSTRACT FROM AUTHOR]
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Titel: |
Comparison of steroidogenic pathways among normoandrogenic and hyperandrogenic polycystic ovary syndrome patients and normal cycling women.
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Autor/in / Beteiligte Person: | Medeiros, Sebastião Freitas ; Barbosa, Jacklyne Silva ; Yamamoto, Márcia Marly Winck |
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Zeitschrift: | Journal of Obstetrics & Gynaecology Research, Jg. 41 (2015-02-01), Heft 2, S. 254-263 |
Veröffentlichung: | 2015 |
Medientyp: | academicJournal |
ISSN: | 1341-8076 (print) |
DOI: | 10.1111/jog.12524 |
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