Old, new and emerging functions of caspases.
In: Cell Death & Differentiation, Jg. 22 (2015-04-01), Heft 4, S. 526-539
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Caspases are proteases with a well-defined role in apoptosis. However, increasing evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and caspase-11 have roles in inflammation and mediating inflammatory cell death by pyroptosis. Similarly, caspase-8 has dual role in cell death, mediating both receptor-mediated apoptosis and in its absence, necroptosis. Caspase-8 also functions in maintenance and homeostasis of the adult T-cell population. Caspase-3 has important roles in tissue differentiation, regeneration and neural development in ways that are distinct and do not involve any apoptotic activity. Several other caspases have demonstrated anti-tumor roles. Notable among them are caspase-2, -8 and -14. However, increased caspase-2 and -8 expression in certain types of tumor has also been linked to promoting tumorigenesis. Increased levels of caspase-3 in tumor cells causes apoptosis and secretion of paracrine factors that promotes compensatory proliferation in surrounding normal tissues, tumor cell repopulation and presents a barrier for effective therapeutic strategies. Besides this caspase-2 has emerged as a unique caspase with potential roles in maintaining genomic stability, metabolism, autophagy and aging. The present review focuses on some of these less studied and emerging functions of mammalian caspases. [ABSTRACT FROM AUTHOR]
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Old, new and emerging functions of caspases.
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Autor/in / Beteiligte Person: | Shalini, S ; Dorstyn, L ; Dawar, S ; Kumar, S |
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Zeitschrift: | Cell Death & Differentiation, Jg. 22 (2015-04-01), Heft 4, S. 526-539 |
Veröffentlichung: | 2015 |
Medientyp: | academicJournal |
ISSN: | 1350-9047 (print) |
DOI: | 10.1038/cdd.2014.216 |
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