In Vitro Antiparasitic Activity and Chemical Composition of the Essential Oil Obtained from the Fruits of Piper cubeba.
In: Planta Medica, Jg. 79 (2013-11-15), Heft 17, S. 1653-1655
serialPeriodical
Zugriff:
Protozoans of the trypanosomatid family cause the neglected tropical diseases leishmaniasis and trypanosomiasis, for which few drugs are available. In this context our group has recently reported that the essential oil obtained by steam distillation of the fruits of Piper cubeba is active against Schistosoma mansoni. Therefore, we have investigated the in vitro effects of the essential oil against the trypomastigote and amastigote forms of Trypanosoma cruzi isolated from an LLCMK 2 cell line culture and the promastigote forms of Leishmania amazonensis. The in vitro activity of the essential oil against trypomastigotes of T. cruzi increased upon rising concentrations, giving IC 50 values of 45.5 and 87.9 μg·mL -1 against trypomastigotes and amastigotes, respectively. The essential oil was not active against L. amazonensis, since it displayed lyses of only 24% at 400 μg·mL -1 , and an IC 50 of 326.5 μg·mL -1 . Therefore, the essential oil should be further investigated to determine the compounds responsible for the observed activities, as well as its mechanism of action. [ABSTRACT FROM AUTHOR]
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Titel: |
In Vitro Antiparasitic Activity and Chemical Composition of the Essential Oil Obtained from the Fruits of Piper cubeba.
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Autor/in / Beteiligte Person: | Esperandim, Viviane Rodrigues ; da Silva Ferreira, Daniele ; Sousa Rezende, Karen Cristina ; Magalhães, Lizandra Guidi ; Souza, Julia Medeiros ; Pauletti, Patrícia Mendonça ; Januário, Ana Helena ; da Silva de Laurentz, Rosangela ; Bastos, Jairo Kenupp ; Símaro, Guilherme Venâncio ; Cunha, Wilson Roberto ; e Silva, Márcio Luis Andrade |
Zeitschrift: | Planta Medica, Jg. 79 (2013-11-15), Heft 17, S. 1653-1655 |
Veröffentlichung: | 2013 |
Medientyp: | serialPeriodical |
ISSN: | 0032-0943 (print) |
DOI: | 10.1055/s-0033-1351022 |
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