Clinical characteristics of the mixed form of neuroendocrine tumor in the lung: A retrospective study in 2501 lung cancer cases.
In: Thoracic Cancer, Jg. 6 (2015), Heft 1, S. 25-30
Online
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Zugriff:
Background: A neuroendocrine tumor (NET) is a special kind of epithelial tumor with predominant neuroendocrine differentiation, which arises throughout the body, including the lung. A subpopulation of lung cancer patients suffer from the mixed (combined) form of NET with components of non-neuroendocrine carcinoma. However, the clinical characteristics of the mixed form of NET are not well established. Methods: We analyzed 2501 consecutive cases of primary lung cancer from 2009 to 2011. The diagnosis, histology, therapy, and outcome were collected. Results: A total of 22 patientswere enrolled.The occurrence rate of lung cancer was 0.9%.Neither gender (1.2% and 0.3% for male and female, respectively,P = 0.35) nor age (0.6% and 1.3% for patients aged ⩽60 and >60, respectively, P = 0.13) was associated with the onset of this disease; however it has become more frequent in recent years (0.6% and 1.6% at the time ⩽ and >2010 respectively, P = 0.03). This cohort of 22 patients had a median survival of 60.0 months (95% confidence interval: 14.3- 105.6 months).Patientswith metastatic disease (60 months and not reached [NR],P = 0.18) or a small-cell lung cancer component tended to have a shorter survival (35 months and NR, P = 0.16). Patients who underwent surgery had a significantly longer survival period (NR and 17.0 months, P = 0.001). Conclusions: Amixed formof NETin the lung is a rare disease.While stage and histology might influence prognosis, surgery is the critical factor for long-termsurvival. [ABSTRACT FROM AUTHOR]
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Clinical characteristics of the mixed form of neuroendocrine tumor in the lung: A retrospective study in 2501 lung cancer cases.
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Autor/in / Beteiligte Person: | Li, Dong‐Hai ; Wang, Chun ; Chen, Hui‐Jiao ; Huang, Hui ; Ding, Zhen‐Yu |
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Zeitschrift: | Thoracic Cancer, Jg. 6 (2015), Heft 1, S. 25-30 |
Veröffentlichung: | 2015 |
Medientyp: | academicJournal |
ISSN: | 1759-7706 (print) |
DOI: | 10.1111/1759-7714.12128 |
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