Higher Cardiovascular Risk in Common Variable Immunodeficiency and X-Linked Agammaglobulinaemia Patients.
In: Annals of Nutrition & Metabolism, Jg. 66 (2015-08-01), Heft 4, S. 237-241
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Zugriff:
Introduction: Common variable immunodeficiency and X-linked agammaglobulinaemia are primary immunodeficiencies classified as antibody deficiencies, and they both result in hypogammaglobulinaemia. Objective: Evaluate the lipid profile and other cardiovascular risk biomarkers in CVID and XLA patients. Methods: In total, 24 patients and 12 healthy controls matched by age and gender were included in the study. We evaluated anthropometric measurements, and seric total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), apo A-I, small dense LDL (sdLDL), C-reactive protein (CRP), and tumour necrosis factor alpha (TNF-alpha), myeloperoxidase (MPO), cholesteryl ester transfer protein (CETP), and lecithin cholesterol acyltransferase (LCAT) were assessed. Results: CRP (p = 0.008) and TNF-alpha (p < 0.001) concentrations were significantly higher, whereas HDL-c (p = 0.025) and apo A-I (p = 0.013) levels were significantly lower in patients than in the controls. In the patient group, a negative and significant correlation was observed between HDL-c and TNF-alpha (r = -0.406; p = 0.049) and between HDL-c and TG (r = -0.641; p = 0.001). Conclusion: Common variable immunodeficiency and X-linked agammaglobulinaemia patients presented themselves with increased inflammatory markers associated with a decreased HDL-c and apo A-I levels, which can predispose to a high cardiovascular risk. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
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Higher Cardiovascular Risk in Common Variable Immunodeficiency and X-Linked Agammaglobulinaemia Patients.
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Autor/in / Beteiligte Person: | Vieira, Daniele Gonçalves ; Costa-Carvalho, Beatriz Tavares ; Hix, Sonia ; da Silva, Rosangela ; Correia, Milena S.G. ; Sarni, Roseli Oselka Saccardo |
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Zeitschrift: | Annals of Nutrition & Metabolism, Jg. 66 (2015-08-01), Heft 4, S. 237-241 |
Veröffentlichung: | 2015 |
Medientyp: | academicJournal |
ISSN: | 0250-6807 (print) |
DOI: | 10.1159/000435818 |
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