Cerebrospinal Fluid Anti-Amyloid-β Autoantibodies and Amyloid PET in Cerebral Amyloid Angiopathy-Related Inflammation.
In: Journal of Alzheimer's Disease, Jg. 50 (2016-03-01), Heft 1, S. 1-7
academicJournal
Zugriff:
We report a biomarker and genetic evaluation of four patients with cerebral amyloid angiopathy-related inflammation (CAA-ri) treated with corticosteroids. Patients presented with focal symptomatology and cognitive impairment. MRI revealed cortical microbleeds and asymmetrical hyperintense white matter lesions (WML). Cerebrospinal fluid (CSF) biomarker analyses showed increased anti-Aβ autoantibodies, t-Tau, and p-Tau and decreased Aβ40 and Aβ42. After treatment, focal symptomatology disappeared, and WML and anti-Aβ autoantibodies decreased. The APOEɛ4 allele was overrepresented. Florbetapir-PET showed cortical deposition with lower retention in swollen areas. In the case of suspected CAA-ri, both CSF anti-Aβ autoantibodies levels and Florbetapir-PET could provide highly useful data to guide the correct diagnosis. [ABSTRACT FROM AUTHOR]
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Titel: |
Cerebrospinal Fluid Anti-Amyloid-β Autoantibodies and Amyloid PET in Cerebral Amyloid Angiopathy-Related Inflammation.
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Autor/in / Beteiligte Person: | Carmona-Iragui, María ; Fernández-Arcos, Ana ; Alcolea, Daniel ; Piazza, Fabrizio ; Morenas-Rodriguez, Estrella ; Antón-Aguirre, Sofía ; Sala, Isabel ; Clarimon, Jordi ; Dols-Icardo, Oriol ; Camacho, Valle ; Sampedro, Frederic ; Munuera, Josep ; Nuñez-Marin, Fidel ; Lleó, Alberto ; Fortea, Juan ; Gómez-Ansón, Beatriz ; Blesa, Rafael |
Zeitschrift: | Journal of Alzheimer's Disease, Jg. 50 (2016-03-01), Heft 1, S. 1-7 |
Veröffentlichung: | 2016 |
Medientyp: | academicJournal |
ISSN: | 1387-2877 (print) |
DOI: | 10.3233/JAD-150614 |
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