Herpes Simplex Virus Type-2 Cervicovaginal Shedding Among Women Living With HIV-1 and Receiving Antiretroviral Therapy in Burkina Faso: An 8-Year Longitudinal Study.
In: Journal of Infectious Diseases, Jg. 213 (2016-03-01), Heft 5, S. 731-737
Online
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Zugriff:
Background: The impact of antiretroviral therapy (ART) on herpes simplex virus type-2 (HSV-2) replication is unclear. The aim of this study was to assess factors associated with cervicovaginal HSV-2 DNA shedding and genital ulcer disease (GUD) in a cohort of women living with human immunodeficiency virus type-1 (HIV-1) in Burkina Faso. Methods: Participants were screened for cervicovaginal HSV-2 DNA, GUD, cervicovaginal and systemic HIV-1 RNA, and reproductive tract infections every 3-6 months over 8 years. Associations with HSV-2 shedding and quantity were examined using random-effects logistic and linear regression, respectively. Results: Of the 236 women with data on HSV-2 shedding, 151 took ART during the study period. Cervicovaginal HSV-2 DNA was detected in 42% of women (99 of 236) in 8.2% of visits (151 of 1848). ART was associated with a reduction in the odds of HSV-2 shedding, which declined for each year of ART use (odds ratio [OR], 0.74; 95% confidence interval [CI], .59-.92). In the multivariable model, the impact of ART was primarily associated with suppression of systemic HIV-1 RNA (adjusted OR, 0.32; 95% CI, .15-.67). A reduction in the odds of GUD was also observed during ART, mainly in those with HIV-1 suppression (adjusted OR, 0.53; 95% CI, .25-1.11). Conclusions: ART is strongly associated with a decrease in cervicovaginal HSV-2 shedding, and the impact was sustained over several years. [ABSTRACT FROM AUTHOR]
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Titel: |
Herpes Simplex Virus Type-2 Cervicovaginal Shedding Among Women Living With HIV-1 and Receiving Antiretroviral Therapy in Burkina Faso: An 8-Year Longitudinal Study.
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Autor/in / Beteiligte Person: | Low, Andrea J. ; Nagot, Nicolas ; Weiss, Helen A. ; Konate, Issouf ; Kania, Dramane ; Segondy, Michel ; Meda, Nicolas ; van de Perre, Philippe ; Mayaud, Philippe ; Yerelon Study Group |
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Zeitschrift: | Journal of Infectious Diseases, Jg. 213 (2016-03-01), Heft 5, S. 731-737 |
Veröffentlichung: | 2016 |
Medientyp: | academicJournal |
ISSN: | 0022-1899 (print) |
DOI: | 10.1093/infdis/jiv495 |
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