Dairy Consumption Lowers Systemic Inflammation and Liver Enzymes in Typically Low-Dairy Consumers with Clinical Characteristics of Metabolic Syndrome.
In: Journal of the American College of Nutrition, Jg. 35 (2016-04-01), Heft 3, S. 255-261
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Zugriff:
Objectives: A 6-week cross-over study design was used to determine the effect of increased dairy consumption in typically low-dairy consumers (n = 37) with metabolic syndrome (MetS) on systemic inflammation and hepatic enzymes. Methods: This was a randomized study in which participants consumed low-fat dairy (LFD) (10 oz 1% milk, 6 oz nonfat yogurt, 4 oz 2% cheese) or a carbohydrate-based control (CNT) (1.5 oz granola bar and 12 oz 100% juice) for 6 weeks. After a 4-week washout, they were allocated to the alternate dietary treatment. Inflammatory status was assessed by fasting plasma concentrations of C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), and monocyte chemoattractant -1 (MCP-1). In addition, gene expression of interleukin (IL)-1, IL-6, and TNF-α was evaluated in peripheral blood mononuclear cells isolated from a subset of 17 subjects (13 women, 3 men) at the end of each dietary period. Liver enzymes were also assessed to evaluate whether dairy components would affect hepatic function. Results: Participants had lower concentrations of both hepatic alanine aminotransferase (p < 0.05) and aspartate aminotransferase (p < 0.005) after the LFD period. No significant changes in any of the plasma inflammatory compounds were found when all data were analyzed together. In contrast, expression of IL-1b and IL-6 were reduced by 46% and 63%, respectively, compared to the control period. When stratified by gender, women had lower TNF-α, (p = 0.028) and MCP-1 (p = 0.001) following LFD consumption compared to CNT. In addition, hepatic steatosis index scores were significantly lower (p < 0.001) during the LFD period. Conclusions: We conclude that three dairy servings per day improved both liver function and systemic inflammation in subjects with MetS. [ABSTRACT FROM AUTHOR]
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Dairy Consumption Lowers Systemic Inflammation and Liver Enzymes in Typically Low-Dairy Consumers with Clinical Characteristics of Metabolic Syndrome.
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Autor/in / Beteiligte Person: | Dugan, Christine E. ; Aguilar, David ; Park, Young-Ki ; Lee, Ji-Young ; Fernandez, Maria Luz |
Zeitschrift: | Journal of the American College of Nutrition, Jg. 35 (2016-04-01), Heft 3, S. 255-261 |
Veröffentlichung: | 2016 |
Medientyp: | academicJournal |
ISSN: | 0731-5724 (print) |
DOI: | 10.1080/07315724.2015.1022637 |
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