Association of Frontotemporal Dementia GWAS Loci with Late-Onset Alzheimer's Disease in a Northern Han Chinese Population.
In: Journal of Alzheimer's Disease, Jg. 52 (2016-07-01), Heft 1, S. 43-50
academicJournal
Zugriff:
Background: Both Alzheimer's disease (AD) and frontotemporal dementia (FTD) are a class of neurodegenerative diseases. Strong similarities in cerebrospinal fluid biomarker, imaging markers, and disease progression profiles suggest that some or most of the pathophysiology is shared between AD and FTD. A recent large genome-wide association study reported several single nucleotide polymorphisms (SNPs) at the RAB38, RAB38/CTSC, HLA-DRA/HLA-DRB5, and BTNL2 in association with FTD. Objective: To explore whether these SNPs are associated with AD risk. Methods: We conducted a case-control study to investigate the association of FTD-associated loci in 2338 Han Chinese subjects. Results: We observed significant differences in genotype distributions of rs302668 (pc = 0.025), rs9268877 (pc = 0.025), rs9268856 (p < 0.001), and rs1980493 (pc = 0.045) between cases and controls. The SNPs rs16913634 for RAB38/CTSC was unrelated to LOAD risk (p = 0.088). Conclusion: The SNPs rs302668 in RAB38, rs9268877 and rs9268856 polymorphism in HLA-DRA/HLA-DRB5, and rs1980493 polymorphism in BTNL2 might play a role in the susceptibility to late-onset AD in the Han Chinese population. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Alzheimer's Disease is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Association of Frontotemporal Dementia GWAS Loci with Late-Onset Alzheimer's Disease in a Northern Han Chinese Population.
|
---|---|
Autor/in / Beteiligte Person: | Tan, Chen-Chen ; Wan, Yu ; Tan, Meng-Shan ; Zhang, Wei ; Wang, Zi-Xuan ; Sun, Fu-Rong ; Miao, Dan ; Tan, Lan ; Yu, Jin-Tai |
Zeitschrift: | Journal of Alzheimer's Disease, Jg. 52 (2016-07-01), Heft 1, S. 43-50 |
Veröffentlichung: | 2016 |
Medientyp: | academicJournal |
ISSN: | 1387-2877 (print) |
DOI: | 10.3233/JAD-151073 |
Schlagwort: |
|
Sonstiges: |
|