Dietary Lipid Type, Rather Than Total Number of Calories, Alters Outcomes of Enteric Infection in Mice.
In: Journal of Infectious Diseases, Jg. 213 (2016-06-01), Heft 11, S. 1846-1856
Online
academicJournal
Zugriff:
Dietary lipids modulate immunity, yet the means by which specific fatty acids affect infectious disease susceptibility remains unclear. Deciphering lipid-induced immunity is critical to understanding the balance required for protecting against pathogens while avoiding chronic inflammatory diseases. To understand how specific lipids alter susceptibility to enteric infection, we fed mice isocaloric, high-fat diets composed of corn oil (rich in n-6 polyunsaturated fatty acids [n-6 PUFAs]), olive oil (rich in monounsaturated fatty acids), or milk fat (rich in saturated fatty acids) with or without fish oil (rich in n-3 PUFAs). After 5 weeks of dietary intervention, mice were challenged with Citrobacter rodentium, and pathological responses were assessed. Olive oil diets resulted in little colonic pathology associated with intestinal alkaline phosphatase, a mucosal defense factor that detoxifies lipopolysaccharide. In contrast, while both corn oil and milk fat diets resulted in inflammation-induced colonic damage, only milk fat induced compensatory protective responses, including short chain fatty acid production. Fish oil combined with milk fat, unlike unsaturated lipid diets, had a protective effect associated with intestinal alkaline phosphatase activity. Overall, these results reveal that dietary lipid type, independent of the total number of calories associated with the dietary lipid, influences the susceptibility to enteric damage and the benefits of fish oil during infection. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Dietary Lipid Type, Rather Than Total Number of Calories, Alters Outcomes of Enteric Infection in Mice.
|
---|---|
Autor/in / Beteiligte Person: | DeCoffe, Daniella ; Quin, Candice ; Gill, Sandeep K. ; Tasnim, Nishat ; Brown, Kirsty ; Godovannyi, Artem ; Dai, Chuanbin ; Abulizi, Nijiati ; Yee Kwan Chan ; Ghosh, Sanjoy ; Gibson, Deanna L. ; Chan, Yee Kwan |
Link: | |
Zeitschrift: | Journal of Infectious Diseases, Jg. 213 (2016-06-01), Heft 11, S. 1846-1856 |
Veröffentlichung: | 2016 |
Medientyp: | academicJournal |
ISSN: | 0022-1899 (print) |
DOI: | 10.1093/infdis/jiw084 |
Schlagwort: |
|
Sonstiges: |
|