Histopathological Evaluation of the Effectiveness of Glycyrrhizic Acid as a Radioprotector Against the Development of Radiation-Induced Lung Fibrosis.
In: Iranian Journal of Radiology, Jg. 13 (2016-04-01), Heft 2, S. 1-6
Online
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Zugriff:
Background: Radiotherapy of the thorax often causes lung inflammation leading to fibrosis. Objectives: The aim of this study was to investigate whether the use of glycyrrhizic acid (GLA) could improve the development of lung fibrosis in irradiated animals. Materials and Methods: Wistar rats were divided into four groups. Group A rats received thoracic irradiation. Rats in group B received GLA and irradiation. Group C received GLA and no irradiation. Group D received no GLA and irradiation. GLA was administered at a dose of 4 mg/kg body weight using an intraperitoneal injection one hour before thoracic irradiation. Radiation therapy was delivered on a Cobalt-60 unit using a single fraction of 16 Gy. The animals were sacrificed at 32 weeks following thoracic irradiation. The lungs were dissected and blind histopathological evaluation was performed. Results: Histopathologically, a decrease (statistically not significant) in the thickening of alveolar or bronchial wall, formation of fibrous bands, and superimposed collagen were noted in the animals in group B as compared to the animals in group A. Conclusion: In this experimental study, administration of GLA one hour before thoracic irradiation may be a protective agent against radiation-induced fibrosis in animals and this model could be used in future studies. [ABSTRACT FROM AUTHOR]
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Histopathological Evaluation of the Effectiveness of Glycyrrhizic Acid as a Radioprotector Against the Development of Radiation-Induced Lung Fibrosis.
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Autor/in / Beteiligte Person: | Refahi, Soheila ; Minaei, Bagher ; Haddadi, Gholam Hassan ; Khoei, Samideh ; Bakhtiarian, Azam ; Pourissa, Masoud ; Takavar, Abbas |
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Zeitschrift: | Iranian Journal of Radiology, Jg. 13 (2016-04-01), Heft 2, S. 1-6 |
Veröffentlichung: | 2016 |
Medientyp: | academicJournal |
ISSN: | 1735-1065 (print) |
DOI: | 10.5812/iranjradiol.21012 |
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