Parallel Profiles of Inflammatory and Effector Memory T Cells in Visceral Fat and Liver of Obesity-Associated Cancer Patients.
In: Inflammation, Jg. 39 (2016-10-01), Heft 5, S. 1729-1736
Online
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Zugriff:
In the midst of a worsening obesity epidemic, the incidence of obesity-associated morbidities, including cancer, diabetes, cardiac and liver disease is increasing. Insights into mechanisms underlying pathological obesity-associated inflammation are lacking. Both the omentum, the principal component of visceral fat, and liver of obese individuals are sites of excessive inflammation, but to date the T cell profiles of both compartments have not been assessed or compared in a patient cohort with obesity-associated disease. We have previously identified that omentum is enriched with inflammatory cytokines, chemokines and T cells. Here, we compared the inflammatory profile of T cells in the omentum and liver of patients with the obesity-associated malignancy oesophageal adenocarcinoma (OAC). Furthermore, we assessed the secreted cytokine profile in OAC patient serum, omentum and liver to assess systemic and local inflammation. We observed parallel T cell cytokine profiles and phenotypes in the omentum and liver of OAC patients, in particular CD69 and inflammatory effector memory T cells. This study reflects similar processes of inflammation and T cell activation in the omentum and liver, and may suggest common targets to modulate pathological inflammation at these sites. [ABSTRACT FROM AUTHOR]
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Titel: |
Parallel Profiles of Inflammatory and Effector Memory T Cells in Visceral Fat and Liver of Obesity-Associated Cancer Patients.
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Autor/in / Beteiligte Person: | Conroy, Melissa ; Galvin, Karen ; Doyle, Suzanne ; Kavanagh, Maria ; Mongan, Ann-Marie ; Cannon, Aoife ; Moore, Gillian ; Reynolds, John ; Lysaght, Joanne |
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Zeitschrift: | Inflammation, Jg. 39 (2016-10-01), Heft 5, S. 1729-1736 |
Veröffentlichung: | 2016 |
Medientyp: | academicJournal |
ISSN: | 0360-3997 (print) |
DOI: | 10.1007/s10753-016-0407-2 |
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