The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo.
In: Science Signaling, Jg. 10 (2017-02-21), Heft 467, S. 1-12
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Zugriff:
Cyanidin, a key flavonoid that is present in red berries and other fruits, attenuates the development of several diseases, including asthma, diabetes, atherosclerosis, and cancer, through its anti-inflammatory effects. We investigated the molecular basis of cyanidin action. Through a structure-based search for small molecules that inhibit signaling by the proinflammatory cytokine interleukin-17A (IL-17A), we found that cyanidin specifically recognizes an IL-17A binding site in the IL-17A receptor subunit (IL-17RA) and inhibits the IL-17A/IL-17RA interaction. Experiments with mice demonstrated that cyanidin inhibited IL-17A-induced skin hyperplasia, attenuated inflammation induced by IL-17-producing T helper 17 (T H 17) cells (but not that induced by T H 1 or T H 2 cells), and alleviated airway hyperreactivity in models of steroid-resistant and severe asthma. Our findings uncover a previously uncharacterized molecular mechanism of action of cyanidin, which may inform its further development into an effective small-molecule drug for the treatment of IL-17A-dependent inflammatory diseases and cancer. [ABSTRACT FROM AUTHOR]
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Titel: |
The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo.
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Autor/in / Beteiligte Person: | Liu, Caini ; Zhu, Liang ; Fukuda, Koichi ; Ouyang, Suidong ; Chen, Xing ; Wang, Chenhui ; Zhang, Cun-jin ; Martin, Bradley ; Gu, Chunfang ; Qin, Luke ; Rachakonda, Suguna ; Aronica, Mark ; Qin, Jun ; Li, Xiaoxia |
Zeitschrift: | Science Signaling, Jg. 10 (2017-02-21), Heft 467, S. 1-12 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
ISSN: | 1945-0877 (print) |
DOI: | 10.1126/scisignal.aaf8823 |
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