A Randomised, Double-Blind, Placebo-Controlled, 5-Weeks' Study of Org 3770 (Mirtazapine) in Major Depression.
In: Human Psychopharmacology: Clinical & Experimental, Jg. 10 (1995-07-15), S. 119-124
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Zugriff:
Fifty-four hospitalised and outpatients with a DSM III diagnosis of major depressive disorder and 21-item HPRSD score of ≥ 18, were randomised to 5 weeksߣ of treatment with either Org 3770 (n = 27; 20–60 mg/day) or placebo (n = 27). The treatment with Org 3770 resulted in statistically significant and clinically relevant differences over placebo at several assessment points and at endpoint. The differences favouring Org 3770 were present on the 17-item HPRSD as well as the MADRS. Similar percentages of patients prematurely withdrew from the study. Adverse experiences were reported by 55% of the Org 3770-and 48% of the placebo-treated patients; the only meaningful difference between the two treatment groups is observed in numbers of patients complaining of dry mouth (8 vs 3 in the Org 3770-and placebo-treatment group, respectively). In conclusion, in this study Org 3770 was proven to be an effective and safe antidepressant. [ABSTRACT FROM AUTHOR]
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Titel: |
A Randomised, Double-Blind, Placebo-Controlled, 5-Weeks' Study of Org 3770 (Mirtazapine) in Major Depression.
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Autor/in / Beteiligte Person: | Khan, M. C. |
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Zeitschrift: | Human Psychopharmacology: Clinical & Experimental, Jg. 10 (1995-07-15), S. 119-124 |
Veröffentlichung: | 1995 |
Medientyp: | academicJournal |
ISSN: | 0885-6222 (print) |
DOI: | 10.1002/hup.470100806 |
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