Prognostic role of neutrophil–lymphocyte ratio in nasopharyngeal carcinoma: A meta-analysis.
In: PLoS ONE, Jg. 12 (2017-07-17), Heft 7, S. 1-12
Online
academicJournal
Zugriff:
Background: Inflammatory markers are used to predict prognosis of nasopharyngeal carcinoma (NPC). Previous reports of neutrophil-to-lymphocyte ratio (NLR) and NPC mortality are inconsistent. This study aimed to quantify the prognostic impact of NLR on NPC. Methods: The primary outcome was overall survival (OS), and the secondary outcomes were disease-specific survival (DSS), progression-free survival (PFS) and distant metastasis-free survival (DMFS). We systematically searched electronic databases, identified articles reporting an association between NLR and NPC prognosis. Hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted, and pooled HRs for each outcome were estimated using random effect models. Results: Nine studies enrolling 5397 patients were included in the analyses. NLR greater than the cutoff value was associated with poor overall survival (HR 1.51, 95% CI 1.27–1.78), disease-specific survival (HR 1.44, 95% CI 1.22–1.71), progression-free survival (HR 1.53, 95% CI 1.22–1.90), and distant metastasis-free survival (HR 1.83, 95% CI 1.14–2.95). Conclusions: Elevated NLR predicts worse OS, DSS, PFS and DMFS in patients with NPC. [ABSTRACT FROM AUTHOR]
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Prognostic role of neutrophil–lymphocyte ratio in nasopharyngeal carcinoma: A meta-analysis.
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Autor/in / Beteiligte Person: | Takenaka, Yukinori ; Kitamura, Takahiro ; Oya, Ryohei ; Ashida, Naoki ; Shimizu, Kotaro ; Takemura, Kazuya ; Yamamoto, Yoshifumi ; Uno, Atsuhiko |
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Zeitschrift: | PLoS ONE, Jg. 12 (2017-07-17), Heft 7, S. 1-12 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
ISSN: | 1932-6203 (print) |
DOI: | 10.1371/journal.pone.0181478 |
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