A Pilot Study to Examine the Effects of an Anti-inflammatory Supplement on Eicosanoid Derivatives in Patients with Chronic Kidney Disease.
In: Journal of Alternative & Complementary Medicine, Jg. 23 (2017-08-01), Heft 8, S. 632-638
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Zugriff:
Background: Chronic kidney disease (CKD) is a progressive disease with an inverse relationship between kidney function and levels of inflammation and oxidative stress. Curcumin and Boswellia serrata have been reported to exert anti-inflammatory effects on the cyclooxygenase and lipoxygenase pathways. Therefore, the purpose of this study was to study the effects of a supplement containing curcumin and B. serrata on eicosanoid derivatives in early stage CKD patients who had not initiated hemodialysis. Methods: Sixteen patients with stage 2 and stage 3 CKD (56.0 ± 16.0 years, 171.4 ± 11.9 cm, 99.3 ± 20.2 kg) were randomized into a treatment group with curcumin and B. serrata or a placebo group. The dependent variables prostaglandin E 2 (PGE 2 ), 5-hydroxyicosatetraenoic acid, 12-hydroxyicosatetraenoic acid, 15-hydroxyicosatetraenoic acid, and 13-hydroxyoctadecadienoic acid were measured both before and after 8 weeks of supplementation. Results were analyzed by using a repeated-measures analysis of covariance for compliance and body-mass index. Results: A significant group effect ( p = 0.05), and a trend for Group × Time interaction ( p = 0.056) were detected for PGE 2 . No significant differences were observed for any other variables. Conclusions: This is the first article of baseline levels of the dependent variables in early stage CKD, and the first article to show a significant effect of these supplements on PGE 2 in early stage CKD. Further studies are needed to determine whether curcumin and B. serrata may be effective means to reduce inflammation in patients with CKD. [ABSTRACT FROM AUTHOR]
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Titel: |
A Pilot Study to Examine the Effects of an Anti-inflammatory Supplement on Eicosanoid Derivatives in Patients with Chronic Kidney Disease.
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Autor/in / Beteiligte Person: | Shelmadine, Brian D. ; Bowden, Rodney G. ; Moreillon, Jennifer J. ; Cooke, Matthew B. ; Yang, Peiying ; Deike, Erika ; Griggs, Jackson O. ; Wilson, Ron L. |
Zeitschrift: | Journal of Alternative & Complementary Medicine, Jg. 23 (2017-08-01), Heft 8, S. 632-638 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
ISSN: | 1075-5535 (print) |
DOI: | 10.1089/acm.2016.0007 |
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