Impact of interstitial lung disease on mortality of patients with rheumatoid arthritis.
In: Rheumatology International, Jg. 37 (2017-10-01), Heft 10, S. 1735-1745
Online
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Zugriff:
To identify the prevalence of interstitial lung disease (ILD) in Korean patients with rheumatoid arthritis (RA) and assess its effect on mortality. A total of 3555 patients with RA, with chest X-ray or chest computed tomography (CT) data at enrollment were extracted from the KORean Observational study Network for Arthritis cohort, a nationwide prospective cohort for patients with RA in Korea. The patients were classified into two groups: (1) an ILD group by chest X-ray or chest CT scan, and (2) a non-ILD group by these modalities. After comparing the characteristics of the groups at enrollment, mortalities were compared using the log-rank test. To explore the impact of ILD on mortality, Cox proportional hazard models were used. Sixty-four patients (1.8%) were identified with ILD. Male and older patients were more common in the ILD group. During a mean follow-up of 24 months, 6 patients (9.4%) in the ILD group and 25 patients (0.7%) in the non-ILD group died; the survival rate was significantly worse in the ILD group ( p < 0.01). On adjusted analysis, ILD was significantly associated with increased mortality (HR 7.89, CI 3.16-19.69, p < 0.01); the risk of death in patients with ILD was even higher than in patients with cardiovascular disease (CVD, HR 4.10, CI 1.79-9.37, p < 0.01). The prevalence of ILD was 1.8% in Korean patients with RA. ILD is a major risk factor for mortality in patients with RA. [ABSTRACT FROM AUTHOR]
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Impact of interstitial lung disease on mortality of patients with rheumatoid arthritis.
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Autor/in / Beteiligte Person: | Kim, Dam ; Cho, Soo-Kyung ; Choi, Chan-Bum ; Choe, Jung-Yoon ; Chung, Won ; Hong, Seung-Jae ; Jun, Jae-Bum ; Jung, Young ; Kim, Tae-Hwan ; Kim, Tae-Jong ; Lee, Hye-Soon ; Lee, Joo-Hyun ; Lee, Jisoo ; Lee, Shin-Seok ; Yoo, Dae-Hyun ; Yoon, Bo ; Song, Jin ; Bae, Sang-Cheol ; Sung, Yoon-Kyoung |
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Zeitschrift: | Rheumatology International, Jg. 37 (2017-10-01), Heft 10, S. 1735-1745 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
ISSN: | 0172-8172 (print) |
DOI: | 10.1007/s00296-017-3781-7 |
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