Maternal venous SHARP1 levels in preeclampsia.
In: Journal of Perinatal Medicine, Jg. 45 (2017-10-01), Heft 7, S. 803-808
academicJournal
Zugriff:
Aim: Owing to its mysterious etiology, pathogenesis of preeclampsia (PE) remains controversial. Here we aimed to compare the levels of an angiogenesis marker, split and hairy related protein-1 (SHARP1), in PE vs. normal pregnancy. Methods: Thirty-one patients with early-onset PE (EOPE), 26 patients with late-onset PE (LOPE), and 33 patients as a control group were recruited for this study in a tertiary referral center in Ankara, Turkey. Maternal venous SHARP1 levels and individual characteristics of the three groups were compared. Results: Age and body mass indices were similar among the three groups. SHARP1 levels in patients with PE (27.7 ± 13.2 ng/mL) were significantly lower than in the control group (34.7 ± 17 ng/mL) (P ± 0.006). Additionally, SHARP1 levels were significantly different among patients in EOPE, LOPE, and control groups (P ± 0.022). Birth weights and Apgar scores in patients in EOPE group were significantly lower than the other two groups and showed a gradual increase from the EOPE group to the LOPE and the control group. Binary logistic regression method demonstrated that maternal venous SHARP1 level was a risk factor for PE. Conclusions: Maternal venous SHARP1 levels in PE are lower than a normal pregnancy. Its clinical applicability and role as a candidate for making sense of the distinctive pathogenesis of the EOPE and LOPE remain to be elucidated. [ABSTRACT FROM AUTHOR]
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Titel: |
Maternal venous SHARP1 levels in preeclampsia.
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Autor/in / Beteiligte Person: | Ersoy, Ali Ozgur ; Oztas, Efser ; Ozler, Sibel ; Tokmak, Aytekin ; Ersoy, Ebru ; Ergin, Merve ; Danisman, Nuri |
Zeitschrift: | Journal of Perinatal Medicine, Jg. 45 (2017-10-01), Heft 7, S. 803-808 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
ISSN: | 0300-5577 (print) |
DOI: | 10.1515/jpm-2015-0437 |
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