The Diagnostic and Prognostic Value of a Dual-Tasking Paradigm in a Memory Clinic.
In: Journal of Alzheimer's Disease, Jg. 61 (2018-01-22), Heft 3, S. 1189-1199
academicJournal
Zugriff:
Background: Daily living requires the ability to perform dual-tasking. As cognitive skills decrease in dementia, performing a cognitive and motor task simultaneously become increasingly challenging and subtle gait abnormalities may even be present in pre-dementia stages. Therefore, a dual-tasking paradigm, such as the Timed Up and Go-Dual Task (TUG-DT), may be useful in the diagnostic assessment of mild cognitive impairment (MCI). Objective: To investigate the diagnostic and prognostic ability of a dual-tasking paradigm in patients with MCI or mild Alzheimer's disease (AD) and to evaluate the association between the dual-tasking paradigm and cerebrospinal fluid (CSF) AD biomarkers. Methods: The study is a prospective cohort study conducted in a clinical setting in two memory clinics. Eighty-six patients were included (28 MCI, 17 AD, 41 healthy controls (HC)). The ability to perform dual-tasking was evaluated by the TUG-DT. Patients underwent a standardized diagnostic assessment and were evaluated to determine progression yearly. Results: ROC curve analysis illustrated a high discriminative ability of the dual-tasking paradigm in separating MCI patients from HC (AUC: 0.78, AUC: 0.82) and a moderate discriminative ability in separating MCI from AD (AUC: 0.73, AUC: 0.55). Performance discriminated clearly between all groups (p < 0.01). Logistic regression analyses revealed a low prognostic value of the dual-tasking paradigm for progression and rate of cognitive decline. A moderately strong correlation between the dual-tasking paradigm and CSF AD biomarkers was observed. Conclusion: In our study, we found that patients with MCI and mild AD have increasing difficulties in dual-tasking compared to healthy elderly. Hence, the dual-tasking paradigm may be a potential complement in the diagnostic assessment in a typical clinical setting. [ABSTRACT FROM AUTHOR]
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Titel: |
The Diagnostic and Prognostic Value of a Dual-Tasking Paradigm in a Memory Clinic.
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Autor/in / Beteiligte Person: | Nielsen, Malene Schjønning ; Simonsen, Anja Hviid ; Siersma, Volkert ; Hasselbalch, Steen Gregers ; Hoegh, Peter ; Nielsen, Malene Schjnning |
Zeitschrift: | Journal of Alzheimer's Disease, Jg. 61 (2018-01-22), Heft 3, S. 1189-1199 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 1387-2877 (print) |
DOI: | 10.3233/JAD-161310 |
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