Effectiveness of topical green tea against multidrug-resistant in cases of primary pyoderma: An open controlled trial.
In: Indian Journal of Dermatology, Venereology & Leprology, Jg. 84 (2018-03-01), Heft 2, S. 163-168
Online
academicJournal
Zugriff:
Background: Antimicrobial activity of green tea against Staphylococcus aureus both in vitro and in vivo has been reported recently. Studies on clinical efficacy and safety of green tea as antibacterial agent against S. aureus in human cases are rare. Objectives: To evaluate the clinical effectiveness and safety of topical green tea on primary pyoderma caused by S. aureus. We also attempted to determine the minimum inhibitory concentration of green tea against S. aureus and methicillin-resistant S. aureus. Methods: Open label, prospective, placebo-controlled study included community-acquired primary pyoderma cases caused by S. aureus. Severity grading was done on a scale of 1-5. Green tea ointment 3% and placebo ointment were used. Cure was defined on the basis of negative culture and assessment of clinical improvement. Minimum inhibitory concentration was determined by agar dilution method. Data were analyzed using Statistical Package for Social Sciences (SPSS) software version 16. Results: Of the 372 patients, 250 received green tea and 122 received placebo. Multidrug-resistant S. aureus was isolated in 89.1% in green tea group and 81.1% in placebo group, respectively. Methicillin-resistant S. aureus was isolated in 24 patients. Cure was seen in 86% in green tea group and 6.6% in placebo group which was statistically very significant. The number of days for comprehensive cure in green tea group was 9.2 ± 6.4 days. All patients with methicillin-resistant S. aureus infection in the green tea group were cured. Minimum inhibitory concentration of green tea against S. aureus was 0.0265 ± 0.008 μg/ml and against methicillin-resistant S. aureus was 0.0205 ± 0.003 μg/ml. Limitations Of the Study: Comparative trial was not conducted in the same patient with different lesions; children less than seven years were not considered as the school authorities did not permit for younger children to be included in the study and true randomization and blinding of investigators were not done. Conclusions: Green tea has a significant antibacterial effect against multidrug-resistant S. aureus. Minimum inhibitory concentration of green tea is established and is promising in methicillin-resistant S. aureus infections. [ABSTRACT FROM AUTHOR]
Copyright of Indian Journal of Dermatology, Venereology & Leprology is the property of Scientific Scholar LLC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Effectiveness of topical green tea against multidrug-resistant in cases of primary pyoderma: An open controlled trial.
|
---|---|
Autor/in / Beteiligte Person: | Umashankar, Nagaraju ; Pemmanda, Belliappa ; Gopkumar, P ; Hemalatha, A ; Sundar, Priya ; Prashanth, H ; Hemalatha, A J ; Sundar, Priya K ; Prashanth, H V |
Link: | |
Zeitschrift: | Indian Journal of Dermatology, Venereology & Leprology, Jg. 84 (2018-03-01), Heft 2, S. 163-168 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 0378-6323 (print) |
DOI: | 10.4103/ijdvl.IJDVL_207_16 |
Schlagwort: |
|
Sonstiges: |
|