Progress and Challenges in Frontotemporal Dementia Research: A 20-Year Review.
In: Journal of Alzheimer's Disease, Jg. 62 (2018-03-01), Heft 3, S. 1467-1480
academicJournal
Zugriff:
The landscape of frontotemporal dementia (FTD) has evolved remarkably in recent years and is barely recognizable from two decades ago. Knowledge of the clinical phenomenology, cognition, neuroimaging, genetics, pathology of the different subtypes of FTD, and their relations to other neurodegenerative conditions, has increased rapidly, due in part, to the growing interests into these neurodegenerative brain conditions. This article reviews the major advances in the field of FTD over the past 20 years, focusing primarily on the work of Frontier, the frontotemporal dementia clinical research group, based in Sydney, Australia. Topics covered include clinical presentations (cognition, behavior, neuroimaging), pathology, genetics, and disease progression, as well as interventions and carer directed research. This review demonstrates the improvement in diagnostic accuracy and capacity to provide advice on genetic risks, prognosis, and outcome. The next major challenge will be to capitalize on these research findings to develop effective disease modifying drugs, which are currently lacking. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Alzheimer's Disease is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Progress and Challenges in Frontotemporal Dementia Research: A 20-Year Review.
|
---|---|
Autor/in / Beteiligte Person: | Perry ; Avila ; Zhu ; Hodges, John R. ; Piguet, Olivier |
Zeitschrift: | Journal of Alzheimer's Disease, Jg. 62 (2018-03-01), Heft 3, S. 1467-1480 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 1387-2877 (print) |
DOI: | 10.3233/JAD-171087 |
Schlagwort: |
|
Sonstiges: |
|