The regular use of an emollient improves symptoms of atopic dermatitis in children: a randomized controlled study.
In: Journal of the European Academy of Dermatology & Venereology, Jg. 32 (2018-07-01), Heft 7, S. 1180-1187
Online
academicJournal
Zugriff:
Abstract: Background: Emollients are considered as a first‐line therapy for the treatment of atopic dermatitis (AD). However, evidence‐based proof that the regular use of emollients reduces AD severity is lacking. Objective: To assess whether the regular use of emollients results in a reduction in AD severity in children with AD. Methods: In this multicentre randomized, parallel group, open‐label study, children with mild‐to‐moderate AD were recruited during a flare. After flare resolution with a topical corticosteroid, patients were randomized to V0034CR emollient, reference emollient or no emollient (1:1:1 ratio), for 12 weeks. AD severity was assessed regularly by physicians [Scoring for Atopic Dermatitis (SCORAD) and subcomponents, IGA] and by parents (PO‐SCORAD and POEM). Results: A total of 335 patients were randomized to V0034CR (n = 111), reference emollient (n = 116) or no emollient (n = 108). After 12 weeks of treatment, SCORAD score was reduced by 5.28 points in the V0034CR group and by 3.36 points in the reference emollient group compared with the no emollient group (+4 points; P < 0.001 in both emollient groups vs. no emollient group). In a similar manner, PO‐SCORAD score was reduced by 4.88 and 2.67 points in the V0034CR and reference emollient groups, respectively, but increased by 2.90 points in the no emollient group (P < 0.001). Similar results were observed for POEM. A continuous decrease in all scores was observed over the 12‐week treatment period. At the end of the study, the percentage of patients in complete remission (i.e. without a new flare over the treatment period) was higher in the V0034CR (59.5%) and reference emollient (44.3%) groups than in the no emollient group (29.8%; P < 0.001). Conclusion: These results demonstrate that the regular use of emollients in children with mild‐to‐moderate AD reduces the severity of symptoms and, therefore, support their use as a first‐line treatment for these patients. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the European Academy of Dermatology & Venereology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
The regular use of an emollient improves symptoms of atopic dermatitis in children: a randomized controlled study.
|
---|---|
Autor/in / Beteiligte Person: | Tiplica, G. S. ; Boralevi, F. ; Konno, P. ; Malinauskiene, L. ; Kaszuba, A. ; Laurens, C. ; Saint‐aroman, M. ; Delarue, A. |
Link: | |
Zeitschrift: | Journal of the European Academy of Dermatology & Venereology, Jg. 32 (2018-07-01), Heft 7, S. 1180-1187 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 0926-9959 (print) |
DOI: | 10.1111/jdv.14849 |
Schlagwort: |
|
Sonstiges: |
|