Vitamin D<subscript>3</subscript>-fortified milk did not affect glycemic control, lipid profile, and anthropometric measures in patients with type 2 diabetes, a triple-blind randomized clinical trial.
In: European Journal of Clinical Nutrition, Jg. 72 (2018-08-01), Heft 8, S. 1083-1092
Online
academicJournal
Zugriff:
Background/objectives: The effect of vitamin D on glycemic status of diabetes patients is controversial. The objective was to assess the effect of vitamin D3-fortified milk on cardiometabolic markers of patients with type 2 diabetes. Subjects/methods: In this randomized triple-blind, placebo-controlled trial, 102 patients (34 males and 68 females) aged 31-74 years with type 2 diabetes were randomized to receive either 250 ml unfortified or 250 ml 1000 IU vitamin D3-fortified milk daily for 9 weeks. Anthropometric characteristics, blood pressure, and serum levels of glucose, insulin, and lipids were determined at baseline and after 9 weeks. Results: Serum 25-hydroxy vitamin D concentrations improved in the fortified milk group compared to the control group (+14 ± 20 vs. +4 ± 17 ng/ml; P = 0.001). Both groups showed significant increases in serum calcium (P < 0.01) and decreases in total cholesterol, waist and hip circumference, and systolic and diastolic blood pressure (P < 0.001). Also, there was a significant reduction in body mass index of fortified milk group (P < 0.001). None of these changes were statistically significant between the two groups. Glycosylated hemoglobin (HbA1c) significantly decreased in both groups with a more remarkable reduction in the plain milk consumers, making a significant between-group difference (7.5% compared to 3.1%; P = 0.01). Conclusions: Overall, daily consumption of one cup of milk containing 1000 IU vitamin D3 for 9 weeks substantially improved vitamin D deficiency in patients with type 2 diabetes but it did not affect cardiometabolic parameters over that of plain milk. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Clinical Nutrition is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Vitamin D<subscript>3</subscript>-fortified milk did not affect glycemic control, lipid profile, and anthropometric measures in patients with type 2 diabetes, a triple-blind randomized clinical trial.
|
---|---|
Autor/in / Beteiligte Person: | Salehi, Saedeh ; Sadeghi, Fatemeh ; Akhlaghi, Masoumeh ; Hanifpour, Mohammad Amin ; Roshanzamir, Mahdi |
Link: | |
Zeitschrift: | European Journal of Clinical Nutrition, Jg. 72 (2018-08-01), Heft 8, S. 1083-1092 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 0954-3007 (print) |
DOI: | 10.1038/s41430-017-0062-1 |
Schlagwort: |
|
Sonstiges: |
|