Elevated expression of keratin 17 in oropharyngeal squamous cell carcinoma is associated with decreased survival.
In: Head & Neck, Jg. 40 (2018-08-01), Heft 8, S. 1788-1798
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Abstract: Background: Overexpression of keratin 17 (K17) is highly associated with poor prognosis in squamous cell carcinoma (SCC) of the cervix. This study was performed to (1) determine whether K17 may be a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC) and (2) to establish if K17 expression is associated with human papillomavirus (HPV) status. Methods: Immunohistochemical staining was performed for K17 of oral, oropharyngeal, and laryngeal SCCs, and normal oropharyngeal mucosa. The HPV status was determined using polymerase chain reaction (PCR). Results: Elevated K17 expression was significantly associated with an overall decreased patient survival (P = .02) and, more specifically, in patients with oropharyngeal SCC (P = .01). When controlling for HPV status and tumor location K17 was still a significant predictor of survival (P = .01). Conclusion: Therefore, K17 is a novel prognostic biomarker of poor survival for patients with HNSCCs, controlling for anatomic site and HPV status. [ABSTRACT FROM AUTHOR]
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Elevated expression of keratin 17 in oropharyngeal squamous cell carcinoma is associated with decreased survival.
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Autor/in / Beteiligte Person: | Regenbogen, Elliot ; Mo, Michelle ; Romeiser, Jamie ; Shroyer, A. Laurie W. ; Escobar‐Hoyos, Luisa F. ; Burke, Stephanie ; Shroyer, Kenneth R. |
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Zeitschrift: | Head & Neck, Jg. 40 (2018-08-01), Heft 8, S. 1788-1798 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 1043-3074 (print) |
DOI: | 10.1002/hed.25164 |
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