Comparison of the efficacy of <superscript>177</superscript>Lu-EDTMP, <superscript>177</superscript>Lu-DOTMP and <superscript>188</superscript>Re-HEDP towards bone osteosarcoma: an in vitro study.
In: Journal of Radioanalytical & Nuclear Chemistry, Jg. 319 (2019), Heft 1, S. 51-59
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Zugriff:
Among the radiopharmaceuticals harnessed for palliation of bone pain in osseous metastases patients, 177 Lu labeled phosphonates such as EDTMP (Ethylene diamine tetramethylene phosphonic acid) as well as DOTMP (1,4,7,10-tetraaza-cyclo-dodecane-1,4,7,10 tetraethylene phosphonic acid) and 188 Re-labeled HEDP (1,1-hydroxyethylene diphosphonic acid) seem to be the most favorable for treatment of small and medium/large size bone lesions, respectively. A comparative assessment of 177 Lu-EDTMP, 177 Lu-DOTMP and 188 Re-HEDP in osteosarcoma tumor cell line was carried out to evaluate their relative efficacy. It was found that 188 Re-HEDP is more potent in induction of cell toxicity and apoptosis compared to the 177 Lu-EDTMP and 177 Lu-DOTMP, thus 188 Re-HEDP might have great clinical significance. [ABSTRACT FROM AUTHOR]
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Titel: |
Comparison of the efficacy of <superscript>177</superscript>Lu-EDTMP, <superscript>177</superscript>Lu-DOTMP and <superscript>188</superscript>Re-HEDP towards bone osteosarcoma: an in vitro study.
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Autor/in / Beteiligte Person: | Kumar, Chandan ; Sharma, Rohit ; Vats, Kusum ; Mallia, Madhav B. ; Das, Tapas ; Sarma, H. D. ; Dash, Ashutosh |
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Zeitschrift: | Journal of Radioanalytical & Nuclear Chemistry, Jg. 319 (2019), Heft 1, S. 51-59 |
Veröffentlichung: | 2019 |
Medientyp: | academicJournal |
ISSN: | 0236-5731 (print) |
DOI: | 10.1007/s10967-018-6283-5 |
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