Plasma Epstein-Barr Virus Load as an Early Biomarker and Prognostic Factor of Human Immunodeficiency Virus–related Lymphomas.
In: Clinical Infectious Diseases, Jg. 68 (2019-03-01), Heft 5, S. 834-843
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Zugriff:
Background Epstein-Barr virus (EBV) has been implicated in lymphomagenesis and can be found infecting tumor cells and in plasma at lymphoma diagnosis, especially in human immunodeficiency virus (HIV)-infected patients. Our aim was to evaluate the usefulness of plasma EBV load as biomarker and prognostic factor in HIV-positive patients with lymphomas. Methods EBV loads were measured by polymerase chain reaction in plasma samples of 81 HIV-positive patients' lymphomas at different moments: within 1 year before lymphoma diagnosis, at diagnosis, and at complete response (CR). Control samples included HIV-negative patients with lymphomas and HIV-positive patients without neoplasia or opportunistic infections. Results HIV-positive patients with lymphomas had more frequently-detectable EBV load at lymphoma diagnosis (53%) than either HIV-negative patients with the same lymphoma type (16%; P <.001) or HIV-positive individuals without neoplasia or opportunistic infection (1.2%; P <.001). HIV-positive lymphoma patients with detectable EBV load in plasma at lymphoma diagnosis had statistically significant decrease of EBV load at CR. High EBV load (>5000 copies/mL) at lymphoma diagnosis was an independent negative prognostic factor for overall survival and progression-free survival in HIV-positive patients with lymphomas. Detectable plasma EBV loads identified HIV-positive subjects that would eventually develop lymphoma (area under the curve, 82%; 95% CI: 0.67–0.96). Conclusions Plasma EBV load can be used as a biomarker and as a prognostic factor in HIV-positive patients with lymphomas. The presence of the EBV load in the plasma of an HIV-positive patient can be an early predictor of lymphoma development. [ABSTRACT FROM AUTHOR]
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Plasma Epstein-Barr Virus Load as an Early Biomarker and Prognostic Factor of Human Immunodeficiency Virus–related Lymphomas.
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Autor/in / Beteiligte Person: | Muncunill, Josep ; Baptista, Maria-Joao ; Hernandez-Rodríguez, Águeda ; Dalmau, Judith ; Garcia, Olga ; Tapia, Gustavo ; Moreno, Miriam ; Sancho, Juan-Manuel ; Martínez-Picado, Javier ; Feliu, Evarist ; Mate, José-Luis ; Ribera, Josep-Maria ; Navarro, José-Tomás |
Zeitschrift: | Clinical Infectious Diseases, Jg. 68 (2019-03-01), Heft 5, S. 834-843 |
Veröffentlichung: | 2019 |
Medientyp: | academicJournal |
ISSN: | 1058-4838 (print) |
DOI: | 10.1093/cid/ciy542 |
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