Role of hydrogen bonding in cocrystals and coamorphous solids: indapamide as a case study.

The stronger sulfonamide–pyridine (SO 2 NH 2 …N-Py) and sulfonamide–carboxamide (SO 2 NH 2 …O=C–NH) hydrogen bonds direct the formation of cocrystals, while the weaker sulfonamide–amine (SO 2 NH 2 …N–H) hydrogen bond results in coamorphous products. IDP–PIP and IDP–ARG coamorphous solids exhibit remarkable stability under accelerated conditions. [ABSTRACT FROM AUTHOR]

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