Absence of accessory genes in a divergent simian T-lymphotropic virus type 1 isolated from a bonnet macaque (Macaca radiata).
In: PLoS Neglected Tropical Diseases, Jg. 13 (2019-07-08), Heft 7, S. 1-12
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Background: Primate T-lymphotropic viruses type 1 (PTLV-1) are complex retroviruses infecting both human (HTLV-1) and simian (STLV-1) hosts. They share common epidemiological, clinical and molecular features. In addition to the canonical gag, pol, env retroviral genes, PTLV-1 purportedly encodes regulatory (i.e. Tax, Rex, and HBZ) and accessory proteins (i.e. P12/8, P13, P30). The latter have been found essential for viral persistence in vivo. Methodology/Principal findings: We have isolated a STLV-1 virus from a bonnet macaque (Macaca radiata–Mra18C9), a monkey from India. The complete sequence was obtained and phylogenetic analyses were performed. The Mra18C9 strain is highly divergent from the known PTLV-1 strains. Intriguingly, the Mra18C9 lacks the 3 accessory open reading frames. In order to determine if the absence of accessory proteins is specific to this particular strain, a comprehensive analysis of the complete PTLV-1 genomes available in Genbank was performed and found that the lack of one or many accessory ORF is common among PTLV-1. Conclusion: This study raises many questions regarding the actual nature, role and importance of accessory proteins in the PTLV-1 biology. [ABSTRACT FROM AUTHOR]
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Absence of accessory genes in a divergent simian T-lymphotropic virus type 1 isolated from a bonnet macaque (Macaca radiata).
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Autor/in / Beteiligte Person: | Afonso, Philippe V. ; Fagrouch, Zahra ; Deijs, Martin ; Niphuis, Henk ; Bogers, Willy ; Gessain, Antoine ; van der Hoek, Lia ; Verschoor, Ernst J. |
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Zeitschrift: | PLoS Neglected Tropical Diseases, Jg. 13 (2019-07-08), Heft 7, S. 1-12 |
Veröffentlichung: | 2019 |
Medientyp: | academicJournal |
ISSN: | 1935-2727 (print) |
DOI: | 10.1371/journal.pntd.0007521 |
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