Glycans in the roles of parasitological diagnosis and host–parasite interplay.
In: Parasitology, Jg. 146 (2019-09-01), Heft 10, S. 1217-1232
Online
serialPeriodical
Zugriff:
The investigation of the glycan repertoire of several organisms has revealed a wide variation in terms of structures and abundance of glycan moieties. Among the parasites, it is possible to observe different sets of glycoconjugates across taxa and developmental stages within a species. The presence of distinct glycoconjugates throughout the life cycle of a parasite could relate to the ability of that organism to adapt and survive in different hosts and environments. Carbohydrates on the surface, and in excretory-secretory products of parasites, play essential roles in host–parasite interactions. Carbohydrate portions of complex molecules of parasites stimulate and modulate host immune responses, mainly through interactions with specific receptors on the surface of dendritic cells, leading to the generation of a pattern of response that may benefit parasite survival. Available data reviewed here also show the frequent aspect of parasite immunomodulation of mammalian responses through specific glycan interactions, which ultimately makes these molecules promising in the fields of diagnostics and vaccinology. [ABSTRACT FROM AUTHOR]
Copyright of Parasitology is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Glycans in the roles of parasitological diagnosis and host–parasite interplay.
|
---|---|
Autor/in / Beteiligte Person: | Veríssimo, Carolina De Marco ; Graeff-Teixeira, Carlos ; Jones, Malcolm K. ; Morassutti, Alessandra L. |
Link: | |
Zeitschrift: | Parasitology, Jg. 146 (2019-09-01), Heft 10, S. 1217-1232 |
Veröffentlichung: | 2019 |
Medientyp: | serialPeriodical |
ISSN: | 0031-1820 (print) |
DOI: | 10.1017/S0031182019000465 |
Schlagwort: |
|
Sonstiges: |
|