Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies.
In: Journal of Neurology, Neurosurgery & Psychiatry, Jg. 91 (2020), S. 49-57
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Zugriff:
Objective: Sensory neuropathies (SNs) are often classified as idiopathic even if immunological mechanisms can be suspected. Antibodies against the intracellular domain of the fibroblast growth factor receptor 3 (FGFR3) possibly identify a subgroup of SN affecting mostly the dorsal root ganglion (DRG). The aim of this study was to identify the frequency of anti-FGFR3 antibodies and the associated clinical pattern in a large cohort of patients with SN. Methods: A prospective, multicentric, European and Brazilian study included adults with pure SN. Serum anti-FGRF3 antibodies were analysed by ELISA. Detailed clinical and paraclinical data were collected for each anti-FGFR3-positive patient and as control for anti-FGFR3-negative patients from the same centres ('center-matched'). Results: Sixty-five patients out of 426 (15%) had anti-FGFR3 antibodies, which were the only identified autoimmune markers in 43 patients (66%). The neuropathy was non-length dependent in 89% and classified as sensory neuronopathy in 64%, non-length-dependent small fibre neuropathy in 17% and other neuropathy in 19%. Specific clinical features occurred after 5-6 years of evolution including frequent paresthesia, predominant clinical and electrophysiological involvement of the lower limbs, and a less frequent mixed large and small fibre involvement. Brazilians had a higher frequency of anti-FGFR3 antibodies than Europeans (36% vs 13%, p<0.001), and a more frequent asymmetrical distribution of symptoms (OR 169, 95% CI 3.4 to 8424). Conclusions: Anti-FGFR3 antibodies occur in a subgroup of SN probably predominantly affecting the DRG. Differences between Europeans and Brazilians could suggest involvement of genetic or environmental factors. [ABSTRACT FROM AUTHOR]
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Titel: |
Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies.
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Autor/in / Beteiligte Person: | Tholance, Yannick ; Moritz, Christian Peter ; Rosier, Carole ; Ferraud, Karine ; Lassablière, François ; Reynaud-Federspiel, Evelyne ; França Jr, Marcondes C. ; Martinez, Alberto R. M. ; Camdessanché, Jean-Philippe ; Antoine, Jean-Christophe ; França, Marcondes C Jr ; anti-FGFR3 antibody Study Group |
Zeitschrift: | Journal of Neurology, Neurosurgery & Psychiatry, Jg. 91 (2020), S. 49-57 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 0022-3050 (print) |
DOI: | 10.1136/jnnp-2019-321849 |
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