Effects of Individualized Dialysate Sodium Prescription in Hemodialysis -- Results from a Prospective Interventional Trial.
In: Indian Journal of Nephrology, Jg. 30 (2020), Heft 1, S. 3-7
Online
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Zugriff:
Introduction: Individualized dialysate sodium prescription does affect weight gain, blood pressure (BP), and intradialytic complications. A prospective interventional trial (Dialysate Individualised Sodium (DISO) trial) was conducted to study this issue in Indian patients. Methods: Forty patients on thrice-weekly maintenance hemodialysis (HD) for at least 6 weeks were enrolled. The study was performed in two different phases. In the first phase, 12 consecutive HD sessions were done with a standard dialysate sodium concentration of 140 mEq/L. In the second phase, 12 consecutive HD sessions were done with dialysate sodium concentration set to individualized value (mean of pre-HD sodium concentration multiplied by Donnan coefficient of 0.95). Differences in pre- and post-HD sodium, interdialytic weight gain (IDWG), pre- and post-HD BP, thirst scores, and intradialytic adverse events during both phases were assessed. Results: The mean age of patients was 45.65 years (24 males, 16 females). The mean serum pre-HD sodium level was 138.7 ± 1.7 meq/L in the standard phase and 138.2 ± 2.6meq/L in the individualized phase (P = 0.229). In the standard phase, the mean IDWG was 2.64 ± 1.56 kg and 2.13 ± 0.99 kg in the individualized phase (P = 0.008). The mean pre-HD systolic BP was 138 ± 18 mmHg and 134 ± 17 mmHg in the standard and individualized phases (P = 0.008). There was no difference in intradialytic symptoms, hypotensive episodes or requirement of interventions. Hypertension episodes occurred at a mean value of 2.2 and 1.2 in the standard and individualized phases, respectively (P = 0.010). Conclusion: The use of individualized dialysate sodium level is safe and results in lower IDWG, pre-HD systolic BP, and intradialytic hypertension in patients on HD. [ABSTRACT FROM AUTHOR]
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Effects of Individualized Dialysate Sodium Prescription in Hemodialysis -- Results from a Prospective Interventional Trial.
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Autor/in / Beteiligte Person: | Radhakrishnan, Radhika C. ; Varughese, Santosh ; Chandran, Abitha ; Jacob, Shibu ; David, Vinoi G. ; Alexander, Suceena ; Mohapatra, Anjali ; Valson, Anna T. ; Gopal, Basu ; Palani, C. ; Jose, Arun ; Antonisamy, B. ; Tamilarasi, V. |
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Zeitschrift: | Indian Journal of Nephrology, Jg. 30 (2020), Heft 1, S. 3-7 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 0971-4065 (print) |
DOI: | 10.4103/ijn.IJN_391_18 |
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