بررسی اثر تجویز آبستاتین بر بهبود اضطراب، مرگ سلولی نکروز و آپوپتوزیس در ناحیه هیپوکامپ در مدل سندرم جنین الکلی در موشهای صحرایی (Persian)

Introduction: Among the numerous consequences of prenatal alcohol exposure (PAE) is an increase in anxiety-like behavior that can prove debilitating to daily functioning. Clinical and experimental evidence has shown postnatal alcohol exposure causes inflammation in the hippocampus and reduced neurogenesis among other brain regions. This can occur during early growth due to the low levels of antioxidants in the brain can be harmful and dangerous. Obstatin is a newly discovered peptide with antiinflammatory, antioxidant activity, in various animal models. Methods: Through intragastric intubation, ethanol (5.27 g/kg/day) was administered in male Wistar rat pups on postnatal days 2- 10 (third trimester in humans). The animals received obestatin (1 and 5 μg/kg, S.C.) on postnatal days 2-10. Thirty-six days after birth, the anexity test was performed using elevated plus maze test, and then. The level of necrotic and apoptosis cells death was determined via nissl and TUNEL staining after the behavioral test. Results: Obestatin significantly improved anxiety behavioral deficits (P<0.01), and obestatin treatment could significantly and decreased nissl and tunnel positive cells in the hippocampus of ethanol-exposed rat pups (P<0.01). Conclusion: The result of this study shows that abstatin had a protective effect on neurodegenerative, alcohol-related behaviors, although further research is needed in the future. [ABSTRACT FROM AUTHOR]

Copyright of Knowledge & Health / Dānish va Tandurustī is the property of Shahroud University of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)