十七种食药用菌提取物抗病毒活性筛选. (Chinese)

Using cytotoxicity assay (MTT) and plaque reduction assay* extracts of 17 kinds of edible fungi were evaluated for their antiviral efficacy against the herpes simplex virus 1 (HSV-1) and 2 strains of enterovirus 71 (Ev71), EV71-CSFI4 and EV71-PTPS in vitro. The results showed that water extracts of Amauroder marudis and Sarcodon imbricatus exhibited good antiviral activity. The therapeutic indices (TIs) of A. marudis water extract against HSV-1, EV71-CSFI4 and EV71-PTPS were 32. 17, 30.05 and 21. 55, respectively. The therapeutic indices (TIs) of S. imbricatus water extract against EV71-CSFI4 and EV71-PTPS were 95. 35 and 112. 22, respectively. Therefore, A. marudis and S. imbricatus showed potential antiviral ability to be developed into antiviral therapeutics. [ABSTRACT FROM AUTHOR]

通过MTT法和空斑实验法评价了 17种食药用菌提取物对单纯疱疹病毒1型（herpes simplex virus 1，HSV-1)和肠道病毒71型（enterovirus 71，EV71)的两个不同来源毒株EV71-CSFI4、EV71-PTPS的抑制效 果。结果表明：皱盖假芝（Amauroder marudis)、枣翘鳞肉齿菌(Sarcodon imbricatus)水提物对3种病毒均具 有较好的抑制效果，皱盖假芝水提物对HSV-1、EV71-CSFI4、EV71-PTPS的治疗指数分别为32.17、30.05、 21.55;枣翘鳞肉EV71-CSFI4、EV71-PTPS齿菌水提物对5的治疗指数较髙，分别为95.35、112.22。研究结果 提示皱盖假芝、枣翘鳞肉齿菌水提物具有进一步开发抗病毒产品的潜力。 [ABSTRACT FROM AUTHOR]

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