Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study.
In: Diabetes Care, Jg. 43 (2020-07-01), Heft 7, S. 1553-1556
Online
academicJournal
Zugriff:
Objective: To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD. Research Design and Methods: Asymptomatic patients (8-45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA1c and continuous glucose monitoring over 12 months. Results: Adults had higher CD-seropositivity rates than children (6.8% [95% CI 4.9-8.2%, N = 1,298] vs. 4.7% [95% CI 3.4-5.9%, N = 1,089], P = 0.035) with lower rates of prior CD screening (6.9% vs. 44.2%, P < 0.0001). Fifty-one participants were randomized to a GFD (N = 27) or GCD (N = 24). No HbA1c differences were seen between the groups (+0.14%, 1.5 mmol/mol; 95% CI -0.79 to 1.08; P = 0.76), although greater postprandial glucose increases (4-h +1.5 mmol/L; 95% CI 0.4-2.7; P = 0.014) emerged with a GFD. Conclusions: CD is frequently observed in asymptomatic patients with type 1 diabetes, and clinical vigilance is warranted with initiation of a GFD. [ABSTRACT FROM AUTHOR]
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Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study.
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Autor/in / Beteiligte Person: | Mahmud, Farid H. ; Clarke, Antoine B.M. ; Joachim, Kariym C. ; Assor, Esther ; McDonald, Charlotte ; Saibil, Fred ; Lochnan, Heather A. ; Punthakee, Zubin ; Parikh, Amish ; Advani, Andrew ; Shah, Baiju R. ; Perkins, Bruce A. ; Zuijdwijk, Caroline S. ; Mack, David R. ; Koltin, Dror ; De Melo, Emilia N. ; Hsieh, Eugene ; Mukerji, Geetha ; Gilbert, Jeremy ; Bax, Kevin |
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Zeitschrift: | Diabetes Care, Jg. 43 (2020-07-01), Heft 7, S. 1553-1556 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 0149-5992 (print) |
DOI: | 10.2337/dc19-1944 |
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