Complete Epstein-Barr virus seropositivity in a large cohort of patients with early multiple sclerosis.
In: Journal of Neurology, Neurosurgery & Psychiatry, Jg. 91 (2020-07-01), Heft 7, S. 1-6
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Zugriff:
Objective: To determine the prevalence of antibodies to Epstein-Barr virus (EBV) in a large cohort of patients with early multiple sclerosis (MS). Methods: Serum samples were collected from 901 patients with a clinically isolated syndrome (CIS) or early relapsing-remitting multiple sclerosis (RRMS) participating in the German National MS cohort, a prospective cohort of patients with early MS with stringent inclusion criteria. Epstein-Barr nuclear antigen (EBNA)-1 and viral capsid antigen (VCA) antibodies were measured in diluted sera by chemiluminescence immunoassays (CLIAs). Sera of EBNA-1 and VCA antibody-negative patients were retested undiluted by an EBV IgG immunoblot. For comparison, we retrospectively analysed the EBV seroprevalence across different age cohorts, ranging from 0 to >80 years, in a large hospital population (N=16 163) from Berlin/Northern Germany. Results: EBNA-1 antibodies were detected by CLIA in 839 of 901 patients with CIS/RRMS. Of the 62 patients without EBNA-1 antibodies, 45 had antibodies to VCA as detected by CLIA. In all of the remaining 17 patients, antibodies to EBV were detected by immunoblot. Altogether, 901 of 901 (100%) patients with CIS/RRMS were EBV-seropositive. EBV seropositivity increased with age in the hospital population but did not reach 100% in any of the investigated age cohorts. Conclusion: The complete EBV seropositivity in this large cohort of patients with early MS strengthens the evidence for a role of EBV in MS. It also suggests that a negative EBV serology in patients with suspected inflammatory central nervous system disease should alert clinicians to consider diagnoses other than MS. [ABSTRACT FROM AUTHOR]
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Complete Epstein-Barr virus seropositivity in a large cohort of patients with early multiple sclerosis.
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Autor/in / Beteiligte Person: | Abrahamyan, Sargis ; Eberspächer, Bettina ; Hoshi, Muna-Miriam ; Aly, Lilian ; Luessi, Felix ; Groppa, Sergiu ; Klotz, Luisa ; Meuth, Sven G. ; Schroeder, Christoph ; Grüter, Thomas ; Tackenberg, Björn ; Paul, Friedemann ; Then-Bergh, Florian ; Kümpfel, Tania ; Weber, Frank ; Stangel, Martin ; Bayas, Antonios ; Wildemann, Brigitte ; Heesen, Christoph ; Zettl, Uwe |
Zeitschrift: | Journal of Neurology, Neurosurgery & Psychiatry, Jg. 91 (2020-07-01), Heft 7, S. 1-6 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 0022-3050 (print) |
DOI: | 10.1136/jnnp-2020-322941 |
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