Synthesis and cellular effects of novel 1,3,5-triazine derivatives in DLD and Ht-29 human colon cancer cell lines.
In: Investigational New Drugs, Jg. 38 (2020-08-01), Heft 4, S. 990-1002
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Summary: This study provides new information on the cellular effects of 1,3,5-triazine nitrogen mustards with different peptide groups in DLD and Ht-29 human colon cancer cell lines. A novel series of 2,4,6-trisubstituted 1,3,5-triazine derivatives bearing 2-chloroethyl and oligopeptide moieties was designed and synthesized. The most cytotoxic derivative was triazine with an Ala-Ala-OMe substituent on the ring (compound 7b). This compound induced time- and dose-dependent cytotoxicity in the DLD-1 and HT-29 colon cancer cell lines. The triazine derivative furthermore induced apoptosis through intracellular signaling pathway attenuation. Compound 7b may be a candidate for further evaluation as a chemotherapeutic agent against colorectal cancer. [ABSTRACT FROM AUTHOR]
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Synthesis and cellular effects of novel 1,3,5-triazine derivatives in DLD and Ht-29 human colon cancer cell lines.
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Autor/in / Beteiligte Person: | Wróbel, Agnieszka ; Kolesińska, Beata ; Frączyk, Justyna ; Kamiński, Zbigniew J. ; Tankiewicz-Kwedlo, Anna ; Hermanowicz, Justyna ; Czarnomysy, Robert ; Maliszewski, Dawid ; Drozdowska, Danuta |
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Zeitschrift: | Investigational New Drugs, Jg. 38 (2020-08-01), Heft 4, S. 990-1002 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 0167-6997 (print) |
DOI: | 10.1007/s10637-019-00838-9 |
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