HyPE study: hydroxychloroquine prophylaxis-related adverse events' analysis among healthcare workers during COVID-19 pandemic: a rising public health concern.
In: Journal of Public Health, Jg. 42 (2020-09-01), Heft 3, S. 493-503
Online
academicJournal
Zugriff:
Background The rising burden of Coronavirus disease (COVID-19) has led to the mass use of hydroxychloroquine by healthcare workers (HCWs). Adverse event profile of this drug when used as prophylaxis is not well known in the literature. Methods A retrospective, cross-sectional study was conducted across the country using semi-structured web-based questionnaire among COVID-19 negative and asymptomatic healthcare workers, taking hydroxychloroquine prophylaxis. Descriptive and multivariate logistic-regression models were applied for analysis. Results Of the 166 participants, at least one adverse event was experienced by 37.9% participants, gastrointestinal being the most common (30.7%). Risk was higher in participants <40 years age (odd's ratio (OR): 2.44, 95% confidence interval (CI): 1.18–5.05) and after first dose of hydroxychloroquine (51.2%, OR: 2.38, 95%CI: 1.17–4.84). Hydroxychloroquine prophylaxis was initiated without electrocardiography by 80.1% of HCWs. Only 21.6% of those with cardiovascular disease could get prior ECG. Conclusions A higher incidence of adverse events was observed when results were compared with studies involving patients on long-term hydroxychloroquine therapy. Younger age and first dose were associated with greater incidence of adverse events though all were self-limiting. Monitoring prior and during prophylaxis was inadequate even among those with cardiovascular disease and risk-factors. However, no serious cardiovascular events were reported. [ABSTRACT FROM AUTHOR]
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HyPE study: hydroxychloroquine prophylaxis-related adverse events' analysis among healthcare workers during COVID-19 pandemic: a rising public health concern.
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Autor/in / Beteiligte Person: | Nagaraja, Bada Sharanappa ; Ramesh, Kalhalli Narayanaswamy ; Dhar, Debjyoti ; Mondal, Mahammad Samim ; Dey, Treshita ; Saha, Subhrakamal ; Khan, Mumtaz Ali ; Rutul, Shah Dhiren ; Pratik, Kishore ; Manjula, Jayaram ; Sangeeth, Thuppanattumadam Ananthasubramanian ; Singh, Vikram |
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Zeitschrift: | Journal of Public Health, Jg. 42 (2020-09-01), Heft 3, S. 493-503 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 1741-3842 (print) |
DOI: | 10.1093/pubmed/fdaa074 |
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