Serum Protein Profiling Reveals a Specific Upregulation of the Immunomodulatory Protein Progranulin in Coronavirus Disease 2019.
In: Journal of Infectious Diseases, Jg. 223 (2021-03-01), Heft 5, S. 775-784
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Zugriff:
Background: Severe courses of coronavirus disease 2019 (COVID-19) are associated with elevated levels of interleukin 6 (IL-6). However, there is a growing body of evidence pointing to a broad and more complex disorder of proinflammatory and antiviral responses with disturbed interferon signaling in COVID-19. Methods: In this prospective, single-center registry, we included severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients and patients with similar symptoms and severity of disease but negative for SARS-CoV-2 admitted to the emergency department and compared their serum protein expression profiles. Results: IL-6 abundance was similar in SARS-CoV-2-positive patients (n = 24) compared with SARS-CoV-2-negative controls (n = 61). In contrast, we observed a specific upregulation of the immunomodulatory protein progranulin (GRN). High GRN abundance was associated with adverse outcomes and increased expression of IL-6 in COVID-19. Conclusions: The data from this registry reveal that GRN is specifically upregulated in SARS-CoV-2-positive patients while IL-6 may serve as marker for disease severity. The potential of GRN as a biomarker and a possible impact of increased GRN expression on interferon signaling, virus elimination, and virus-induced lung tissue damage in COVID-19 should be further explored. [ABSTRACT FROM AUTHOR]
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Serum Protein Profiling Reveals a Specific Upregulation of the Immunomodulatory Protein Progranulin in Coronavirus Disease 2019.
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Autor/in / Beteiligte Person: | Rieder, Marina ; Wirth, Luisa ; Pollmeier, Luisa ; Jeserich, Maren ; Goller, Isabella ; Baldus, Niklas ; Schmid, Bonaventura ; Busch, Hans-Joerg ; Hofmann, Maike ; Thimme, Robert ; Rieg, Siegbert ; Kern, Winfried ; Bode, Christoph ; Duerschmied, Daniel ; Lother, Achim |
Zeitschrift: | Journal of Infectious Diseases, Jg. 223 (2021-03-01), Heft 5, S. 775-784 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 0022-1899 (print) |
DOI: | 10.1093/infdis/jiaa741 |
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