Vonoprazan versus lansoprazole in the treatment of artificial gastric ulcers after endoscopic submucossal dissection: a randomized, open-label trial.
In: BMC Gastroenterology, Jg. 21 (2021-05-22), Heft 1, S. 1-6
Online
academicJournal
Zugriff:
Background: Vonoprazan is more potent and longer acting than traditional proton pump inhibitor. Although vonoprazan is expected to be superior to proton pump inhibitor, its efficacy in the treatment of gastric ulcers following endoscopic submucosal dissection (ESD) is not fully understood. The aim of this study was to evaluate the effectiveness of vonoprazan in artificial ulcer healing following ESD. Methods: Patients with gastric tumors were randomly assigned to the vonoprazan group (group V) or lansoprazole group (group L) after ESD. Patients received intravenous lansoprazole (30 mg) twice on the day of ESD. Thereafter, patients were treated with vonoprazan (20 mg/day) in group V or lansoprazole (30 mg/day) in group L. Esophagogastroduodenoscopy was performed 4 and 8 weeks after the ESD. Results: A total of 168 patients were analyzed. The 4-week healing rate for artificial ulcer was not significantly higher in group V versus group L (17/85, 20.0% vs. 14/83, 16.9%, respectively). In addition, there were no significant differences between the 4-week shrinkage rates between the two groups. Postoperative bleeding occurred in none of the patients in group V and three in group L. One patient in group V presented delayed perforation 2 days after ESD. Conclusions: Vonoprazan might not be superior to lansoprazole in the healing of artificial gastric ulcer after ESD. Trial Registration: University hospital Medical Information Network (registration number: UMIN000016642), Registered 27 February 2015, https://www.umin.ac.jp/ctr/index-j.htm. [ABSTRACT FROM AUTHOR]
Copyright of BMC Gastroenterology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Vonoprazan versus lansoprazole in the treatment of artificial gastric ulcers after endoscopic submucossal dissection: a randomized, open-label trial.
|
---|---|
Autor/in / Beteiligte Person: | Kawai, Daisuke ; Takenaka, Ryuta ; Ishiguro, Mikako ; Okanoue, Shotaro ; Gotoda, Tatsuhiro ; Kono, Yoshiyasu ; Takemoto, Koji ; Tsugeno, Hirofumi ; Fujiki, Shigeatsu |
Link: | |
Zeitschrift: | BMC Gastroenterology, Jg. 21 (2021-05-22), Heft 1, S. 1-6 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 1471-230X (print) |
DOI: | 10.1186/s12876-021-01822-5 |
Schlagwort: |
|
Sonstiges: |
|