胞质分裂作用因子10在肺癌诊断及预后中的意义. (Chinese)

Objective: To investigate the expression of cytokinesis factor 10 (Dock10) in lung cancer tissues and adjacent tissues and its significance in the prognosis and diagnosis of lung cancer. Methods: A total of 98 lung cancer patients admitted to our hospital from June 2010 to June 2015 were selected to detect the expression of Dock10 in their lung cancer tissues and adjacent tissues. Analyze the relationship between Dock10 expression and clinical pathological characteristics of patients. Analyze the influencing factors of the patient's prognosis. Analyze the value of Dock10 in the diagnosis of lung cancer and the relationship between its expression and patient prognosis. Results: Dock10 mRNA and protein expression levels and average expression levels in lung cancer tissues were higher than those in adjacent tissues (P<0.05). The expression of Dock10 was related to tumor size, TNM stage and degree of differentiation (P<0.05). The results of COX proportional hazard regression analysis showed that smoking history, TNM stage, degree of differentiation, and Dock10 expression are all influencing factors for the prognosis of lung cancer patients (P<0.05). Receiver operating characteristic (ROC) curve analysis results show that the area under the curve and the best diagnostic cut-off value of Dock10 for diagnosis of lung cancer are 0.894 and 1.877 ng/mL, respectively, which has certain diagnostic value. The 5-year survival rate of patients with low Dock10 expression was higher than that of patients with high Dock10 expression (P<0.05). Conclusion: Dock10 has certain significance for the clinical diagnosis and prognosis of lung cancer, and may be used as a potential auxiliary index for the diagnosis and prognosis of lung cancer. [ABSTRACT FROM AUTHOR]

目的:探讨胞质分裂作用因子10（Dock10）在肺癌组织及癌旁组织中的表达及其在肺癌预后及诊断中的意义。方法:选取2010年6月至2015年6月期间我院收治的肺癌患者98例,检测其肺癌组织及癌旁组织中Dock10的表达情况。分析Dock10表达与患者临床病理特征的关系。分析患者预后的影响因素。分析Dock10在肺癌诊断中的价值及其表达与患者预后的关系。结果:肺癌组织中Dock10 mRNA及蛋白表达水平、平均表达量均高于癌旁组织（P<0.05）。Dock10表达与肿瘤大小、TNM分期、分化程度有关（P<0.05）。COX比例风险回归分析结果显示,吸烟史、TNM分期、分化程度、Dock10表达均为肺癌患者预后的影响因素（P<0.05）。受试者工作特征（ROC）曲线分析结果显示Dock10诊断肺癌的曲线下面积及最佳诊断临界值分别为0.894、1.877 ng/mL,具有一定诊断价值。Dock10低表达患者的5年生存率高于Dock10高表达患者（P<0.05）。结论:Dock10对肺癌的临床诊断和预后具有一定意义,可能作为一种潜在的肺癌诊断和预后评估辅助指标. [ABSTRACT FROM AUTHOR]

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