结直肠癌组织 LRFN4、HMGB2、MAGE-A9的表达及与临床病理特征和预后的关系分析. (Chinese)

To investigate the expression of leucine rich repeat and fibronectin type III domain containing 4 (LRFN4), high mobility group protein B2 (HMGB2), melanoma associated antigen-A9 (MAGE-A9) in colorectal cancer tissues and their relationship with clinicopathological characteristics and prognosis. 102 patients with colorectal cancer treated in our hospital from May 2013 to May 2015 were studied. The expressions of LRFN4, HMGB2 and MAGE-A9 in colorectal cancer tissues and adjacent tissues were detected. The relationship with expression of LRFN4, HMGB2, MAGE-A9 and clinicopathological characteristics were analyzed. The impact of the LRFN4, HMGB2 and MAGE-A9 expressions on the overall survival rate of patients. Cox proportional hazards regression analysis of prognostic factors in patients with colorectal cancer. Compared with adjacent tissues, the positive expressions rates of LRFN4, HMGB2 and MAGE-A9 were up-regulated in colorectal cancer tissues(P<0.05). The expression of LRFN4, HMGB2, MAGE-A9 was correlated with TNM stage and lymph node metastasis (P<0.05). The survival rates of patients with positive expressions LRFN4, HMGB2 and MAGE-A9 were lower than those of patients with negative expressions LRFN4, HMGB2 and MAGE-A9 respectively (P<0.05). Cox proportional hazard regression analysis showed that TNM stage, LRFN4, HMGB2, MAGE-A9 expressions were the factors influencing the prognosis of patients with colorectal cancer (P<0.05). The positive expression rates of LRFN4, HMGB2 and MAGE-A9 in colorectal cancer tissues are up-regulating, which are associated with the progression of colorectal cancer and the prognosis of patients, detection of LRFN4, HMGB2, MAGE-A9 expression is helpful to evaluate the prognosis of patients. [ABSTRACT FROM AUTHOR]

目的:探讨结直肠癌组织富含亮氨酸重复序列/Ⅲ型纤维连接蛋白4（LRFN4）、高迁移率族蛋白B2（HMGB2）、黑色素瘤相关抗原-A9（MAGE-A9）表达与临床病理特征及预后的关系。方法:对2013年5月至2015年5月期间在我院接受治疗的102例结直肠癌患者进行研究。检测结直肠癌组织以及癌旁组织中LRFN4、HMGB2、MAGE-A9表达情况。分析LRFN4、HMGB2、MAGE-A9表达与临床病理特征的关系;分析LRFN4、HMGB2、MAGE-A9表达对患者总生存率的影响。分析影响结直肠癌患者预后的因素。结果:与癌旁组织相比,结直肠癌组织中LRFN4、HMGB2、MAGE-A9表达阳性率上调（P<0.05）。LRFN4、HMGB2、MAGE-A9表达与TNM分期和淋巴结转移相关（P<0.05）。LRFN4、HMGB2、MAGE-A9阳性表达患者的生存率分别低于LRFN4、HMGB2、MAGE-A9阴性表达患者（P<0.05）。Cox比例风险回归分析结果显示,TNM分期、LRFN4、HMGB2、MAGE-A9表达是结直肠癌患者预后的影响因素（P<0.05）。结论:结直肠癌组织中LRFN4、HMGB2、MAGE-A9表达阳性率上调,并与结直肠癌的进展和患者的预后有关,检测LRFN4、HMGB2、MAGE-A9表达情况有助于患者的预后评估。 [ABSTRACT FROM AUTHOR]

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