Comparison of treatments and outcomes of children with juvenile dermatomyositis followed at two European tertiary care referral centers.
In: Rheumatology, Jg. 60 (2021-11-01), Heft 11, S. 5419-5423
Online
academicJournal
Zugriff:
Objectives To compare the treatment approaches and disease outcomes of children with JDM followed in two European tertiary care peadiatric rheumatology centres. Methods The medical notes of patients with JDM seen at Istituto Giannina Gaslini (IGG) of Genoa, Italy or Great Ormond Street Hospital (GOSH) of London, UK between January 2000 and December 2015 within 6 months after disease onset and followed for at least 6 months were reviewed. Demographic, clinical and therapeutic data were collected. At each visit, the caring physician was asked to rate the disease state subjectively. Results A total of 127 patients were included, 88 at GOSH and 39 at IGG. At 24 months, the median values of muscle strength and disease activity were at the normal end of the scale and around three quarters of patients were said to have inactive disease. Also, at 2 years, 38.6% and 36% of British and Italian patients, respectively, had damage. Cyclophosphamide, azathioprine, infliximab, rituximab and mycophenolate mofetil were used more frequently by UK physicians, whereas ciclosporin, intravenous immunoglobulin and hydroxychloroquine were prescribed by Italian physicians. Conclusion This study shows a significant difference in the choice of medications between pediatric rheumatologists practising in the two centres. Despite this, a high proportion of patients had inactive disease at 2 years and there was a low frequency of damage: modern treatments have improved outcomes. [ABSTRACT FROM AUTHOR]
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Comparison of treatments and outcomes of children with juvenile dermatomyositis followed at two European tertiary care referral centers.
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Autor/in / Beteiligte Person: | Varnier, Giulia Camilla ; Consolaro, Alessandro ; Maillard, Susan ; Pilkington, Clarissa ; Ravelli, Angelo |
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Zeitschrift: | Rheumatology, Jg. 60 (2021-11-01), Heft 11, S. 5419-5423 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 1462-0324 (print) |
DOI: | 10.1093/rheumatology/keab089 |
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